The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases
Open accessAbstract
Development, angiogenesis, wound healing, and metastasis all involve the movement of cells in response to changes in the extracellular environment. To determine whether caveolin-1 plays a role in cell migration, we have used fibroblasts from knockout mice. Caveolin-1–deficient cells lose normal cell polarity, exhibit impaired wound healing, and have decreased Rho and increased Rac and Cdc42 GTPase activities. Directional persistency of migration is lost, and the cells show an impaired response to external directional stimuli. Both Src inactivation and p190RhoGAP knockdown restore the wild-type phenotype to caveolin-1–deficient cells, suggesting that caveolin-1 stimulates normal Rho GTP loading through inactivation of the Src–p190RhoGAP pathway. These findings highlight the importance of caveolin-1 in the establishment of cell polarity during directional migration through coordination of the signaling of Src kinase and Rho GTPases.
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Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Cited by
Adhesion signaling – crosstalk between integrins, Src and Rho
Huveneers, S., & Danen, E. H. J. (2009) · Journal of Cell Science · doi:10.1242/jcs.039446 · Cited by 852
Goetz, J. G., Minguet, S., Navarro-Lérida, I., Lazcano, J. J., Samaniego, R., Calvo, E., Tello, M., Osteso-Ibáñez, T., Pellinen, T., Echarri, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.05.040 · Cited by 720
Self-citationSaharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1715 · Cited by 471
Scita, G., & Di Fiore, P. P. (2010) · Nature · doi:10.1038/nature08910 · Cited by 447
Trepat, X., Chen, Z., & Jacobson, K. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110012 · Cited by 406
Metadata
- Authors
- Grande-García, A., Echarri, A., de Rooij, J., Alderson, N. B., Waterman-Storer, C. M., Valdivielso, J. M., & del Pozo, M. A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-05-21
- Volume
- 177
- Issue
- 4
- Pages
- 683-694
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2169364099
- Cited by
- 341
- References
- 1
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Grande-García, A., Echarri, A., de Rooij, J., Alderson, N. B., Waterman-Storer, C. M., Valdivielso, J. M., & del Pozo, M. A. (2007). Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200701006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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