The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The decision to enter mitosis: feedback and redundancy in the mitotic entry network
Open accessAbstract
The decision to enter mitosis is mediated by a network of proteins that regulate activation of the cyclin B–Cdk1 complex. Within this network, several positive feedback loops can amplify cyclin B–Cdk1 activation to ensure complete commitment to a mitotic state once the decision to enter mitosis has been made. However, evidence is accumulating that several components of the feedback loops are redundant for cyclin B–Cdk1 activation during normal cell division. Nonetheless, defined feedback loops become essential to promote mitotic entry when normal cell cycle progression is perturbed. Recent data has demonstrated that at least three Plk1-dependent feedback loops exist that enhance cyclin B–Cdk1 activation at different levels. In this review, we discuss the role of various feedback loops that regulate cyclin B–Cdk1 activation under different conditions, the timing of their activation, and the possible identity of the elusive trigger that controls mitotic entry in human cells.
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Cites
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085
DNA damage checkpoints: from initiation to recovery or adaptation
Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784
Daub, H., Olsen, J. V., Bairlein, M., Gnad, F., Oppermann, F. S., Körner, R., Greff, Z., Kéri, G., Stemmann, O., & Mann, M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.007 · Cited by 594
Cited by
Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events
McCloy, R. A., Rogers, S., Caldon, C. E., Lorca, T., Castro, A., & Burgess, A. (2014) · Cell Cycle · doi:10.4161/cc.28401 · Cited by 853
Shared and separate functions of polo-like kinases and aurora kinases in cancer
Lens, S. M. A., Voest, E. E., & Medema, R. H. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2964 · Cited by 597
Self-citationMüllers, E., Cascales, H. S., Jaiswal, H., Saurin, A. T., & Lindqvist, A. (2014) · Cell Cycle · doi:10.4161/15384101.2015.945831 · Cited by 84
Self-citationLindqvist, A., de Bruijn, M., Macurek, L., Brás, A., Mensinga, A., Bruinsma, W., Voets, O., Kranenburg, O., & Medema, R. H. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.246 · Cited by 75
Self-citationPP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila
Mehsen, H., Boudreau, V., Garrido, D., Bourouh, M., Larouche, M., Maddox, P. S., Swan, A., & Archambault, V. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201804018 · Cited by 52
Metadata
- Authors
- Lindqvist, A., Rodríguez-Bravo, V., & Medema, R. H.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2009-04-13
- Volume
- 185
- Issue
- 2
- Pages
- 193-202
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2172106590
- Cited by
- 565
- References
- 3
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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