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The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella
Open accessAbstract
Cilia and flagella are highly conserved microtubule (MT)-based organelles with motile and sensory functions, and ciliary defects have been linked to several human diseases. The 9 + 2 structure of motile axonemes contains nine MT doublets interconnected by nexin links, which surround a central pair of singlet MTs. Motility is generated by the orchestrated activity of thousands of dynein motors, which drive interdoublet sliding. A key regulator of motor activity is the dynein regulatory complex (DRC), but detailed structural information is lacking. Using cryoelectron tomography of wild-type and mutant axonemes from Chlamydomonas reinhardtii, we visualized the DRC in situ at molecular resolution. We present the three-dimensional structure of the DRC, including a model for its subunit organization and intermolecular connections that establish the DRC as a major regulatory node. We further demonstrate that the DRC is the nexin link, which is thought to be critical for the generation of axonemal bending.
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Cited by
Khalifa, A. A. Z., Ichikawa, M., Dai, D., Kubo, S., Black, C. S., Peri, K., McAlear, T. S., Veyron, S., Yang, S. K., Vargas, J., et al. (2020) · eLife · doi:10.7554/elife.52760 · Cited by 1,676
Motile and non-motile cilia in human pathology: From function to phenotypes
Mitchison, H. M., & Valente, E. M. (2017) · The Journal of Pathology · doi:10.1002/path.4843 · Cited by 448
Wallmeier, J., Nielsen, K. G., Kuehni, C. E., Lucas, J. S., Leigh, M. W., Zariwala, M. A., & Omran, H. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0209-6 · Cited by 403
Structure of the Decorated Ciliary Doublet Microtubule
Ma, M., Stoyanova, M., Rademacher, G., Dutcher, S. K., Brown, A., & Zhang, R. (2019) · Cell · doi:10.1016/j.cell.2019.09.030 · Cited by 290
Clinical Features of Childhood Primary Ciliary Dyskinesia by Genotype and Ultrastructural Phenotype
Davis, S. D., Ferkol, T. W., Rosenfeld, M., Lee, H.-S., Dell, S. D., Sagel, S. D., Milla, C., Zariwala, M. A., Pittman, J. E., Shapiro, A. J., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201409-1672oc · Cited by 277
Metadata
- Authors
- Heuser, T., Raytchev, M., Krell, J., Porter, M. E., & Nicastro, D.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2009-12-14
- Volume
- 187
- Issue
- 6
- Pages
- 921-933
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2108999119
- Cited by
- 351
- References
- 0
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Heuser, T., Raytchev, M., Krell, J., Porter, M. E., & Nicastro, D. (2009). The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella. Journal of Cell Biology. https://doi.org/10.1083/jcb.200908067
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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