Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

Cited by (159)

Items 101–159 of 159

1. Blockade of the BAK Hydrophobic Groove by Inhibitory Phosphorylation Regulates Commitment to Apoptosis
   Abul Azad, Joanna L. Fox, Sabrina Leverrier, Alan Storey · 2012 · PLoS ONE
2. MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers
   Pablo Marco Veras Peixoto, Óscar Teijido, Oygul Mirzalieva, Laurent M. Dejean, Evgeny V. Pavlov, Bruno E. Antonsson, Kathleen Walsh Kinnally · 2015 · Journal of Bioenergetics and Biomembranes
3. Crosstalk between Noxa, Bcl-2, and ceramide in mediating p53-dependent apoptosis in Molt-4 human T-cell leukemia
   Hadile Kobeissy, Rouba Hage‐Sleiman, Zeinab Dakdouk, Lina Kozhaya, Ghassan S. Dbaibo · 2020 · Molecular and Cellular Biochemistry
4. Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5
   Sebastian Rühl, Zhenrui Li, Shagun Srivastava, Luigi Mari, Clifford S. Guy, Mao Yang, Tudor Moldoveanu, Douglas R. Green · 2024 · Cell Death and Differentiation
5. Canonical Bcl-2 Motifs of the Na+/K+ Pump Revealed by the BH3 Mimetic Chelerythrine: Early Signal Transducers of Apoptosis?
   Peter K. Lauf, Judith A. Heiny, Jarek Meller, Michael A. Lepera, Leonid N. Koikov, Gerald M. Alter, Thomas L. Brown, Norma C. Adragna · 2013 · Cellular Physiology and Biochemistry
6. NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS
   Shenggen Yao, Dana Westphal, Jeffrey J. Babon, Geoff V. Thompson, Adeline Y. Robin, Jerry M. Adams, Peter M. Colman, Peter E. Czabotar · 2014 · Archives of Biochemistry and Biophysics
7. The role of cardamom on the hazardous effects of depleted uranium in cerebellum and midbrain of albino rats
   Mona Abdel-Rahman, Mohamed M. Rezk, Seham Abdel-kader · 2017 · Toxicology and Environmental Health Sciences
8. Molecular Determinants for the Activation/Inhibition of Bak Protein by BH3 Peptides
   Guillem Vila-Julià, José M. Granadino‐Roldán, Juan Jesús Pérez, J. Rubio · 2020 · Journal of Chemical Information and Modeling
9. Targeting the B-cell lymphoma 2 anti-apoptotic proteins for cervical cancer treatment
   Siti Fairus Abdul Rahman, Benedict Shi Xiang Lian, Nethia Mohana‐Kumaran · 2020 · Future Oncology
10. Eltrombopag directly activates BAK and induces apoptosis
    Meng Chen, Lei Hu, Xuyuan Bao, Kaiqin Ye, Yunjian Li, Zhiyong Zhang, Scott H. Kaufmann, Jun Xiao, Haiming Dai · 2023 · Cell Death and Disease
11. Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer
    Dongyan Liu, Xiaonan Hou, Wangyu Wu, Valentina Zanfagnin, Yunjian Li, Cristina Correia, Zhiyang Zhao, Chenggang Zhao, Zhirong Liu, Tao Zhang et al. · 2021 · Cell Death and Disease
12. BIM Binding Remotely Regulates BAX Activation: Insights from the Free Energy Landscapes
    Souvik Sinha, Atanu Maity, Shubhra Ghosh Dastidar · 2017 · Journal of Chemical Information and Modeling
13. Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove
    Peng Cheng, Yuzhu Hou, Mingxing Bian, Xueru Fang, Yan Liu, Yuanfang Rao, Shuo Cao, Yanjun Liu, Shuai Zhang, Yanke Chen et al. · 2023 · Communications Biology
14. Study of the Bcl-2 Interactome by BiFC Reveals Differences in the Activation Mechanism of Bax and Bak
    Óscar Gonzalo, Andrea Benedi, Laura Vela, Alberto Anel, Javier Naval, Isabel Marzo · 2023 · Cells
15. Identification of potential natural BCL-2 inhibitors for leukemia through an integrated virtual screening approach
    Uddalak Das, Arnab Mukherjee, K. S. Mukunthan, Jitendra Kumar · 2025 · BMC Pharmacology and Toxicology
16. BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
    Abul Azad, Alan Storey · 2013 · Molecular Cancer
17. Disordered clusters of Bak dimers rupture mitochondria during apoptosis
    Rachel T. Uren, Martin O’Hely, Sweta Iyer, Ray C. Bartolo, Jason M. Brouwer, Amber E. Alsop, Grant Dewson, Ruth M. Kluck · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
18. A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells
    Hema Preethi Subas Satish, Sweta Iyer, Melissa X. Shi, Agnes W. Wong, Karla C. Fischer, Ahmad Z. Wardak, Daisy Sio Seng Lio, Jason M. Brouwer, Rachel T. Uren, Peter E. Czabotar et al. · 2024 · Cell Death and Differentiation
19. Linker Histone H1.2 Directly Activates BAK through the K/RVVKP Motif on the C-Terminal Domain
    R. Schnetler, Sylvia Fanucchi, Tudor Moldoveanu, Gerrit Koorsen · 2020 · Biochemistry
20. The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death
    Jia Jia, Mengqing Li, Yunjian Li, Jun Xiao, Haiming Dai · 2023 · Cell Biology and Toxicology
21. Direct BAKtivation
    Loren D. Walensky · 2013 · Nature Structural & Molecular Biology
22. BAK and BAX: Therapeutic Targets for Acute Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury
    Zejun Xu, F. Meng, Hongjun Yang, Ya-Ling Liu, Kai-Qin Ye, Fei Qin, Dongyan Liu, Haiming Dai · 2025 · Biology
23. The role of Bcl-2 family genes in the physiology and immune response of the Pinctada fucata martensii
    Xiaochen Fang, Bidan Liang, Haiying Liang, Jinzhao Lu · 2023 · Aquaculture
24. Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignancies
    Konstantina Athanasopoulou, Panagiotis G. Adamopoulos, Glykeria N. Daneva, Andreas Scorilas · 2022 · APOPTOSIS
25. Anti-apoptotic BH3-only proteins inhibit Bak-dependent apoptosis
    Sebastian Rühl, Clifford S. Guy, Zhenrui Li, Mao Yang, Tudor Moldoveanu, Douglas R. Green · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
26. BCL-2 Protein Ailesi ve Kanser
    Derya BABACAN · 2023 · Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi
27. Apoptosis as a Therapeutic Target in Chronic Lymphocytic Leukemia
    Christian Billard · 2015 · Lymphoma and Chronic Lymphocytic Leukemias
28. Logical complexity of Bcl-2 family proteins function in the intrinsic apoptosis
    Marián Adamkov · 2019 · Srpski arhiv za celokupno lekarstvo
29. AKT inhibition sensitizes acute leukemia cells to S63845-induced apoptosis
    Yunjian Li, Liang Du, Kaiqin Ye, Xiao Guang Sun, Lei Hu, Shan Gao, Haiming Dai · 2023 · Hematology
30. Therapeutics targeting BCL2 family proteins
    Haiming Dai, X. Wei Meng, Kaiqin Ye, Jia Jia, Scott H. Kaufmann · 2021 · Elsevier eBooks
31. Chk1 activity is required for BAK multimerization in association with PUMA during mitochondrial apoptosis
    Abul Kalam Azad, Alan Storey · 2014 · Cell Communication and Signaling
32. Bim regulation miRrors microRNA 17∼92 cluster expression in endothelial cells in vivo
    X. Wei Meng, Scott H. Kaufmann · 2014 · Cell Death and Differentiation
33. Spontaneous oligomerization of BAK/BAX is suppressed by hetero-dimerization with MCL-1
    Basile I. M. Wicky, Kallol Gupta, Tristan O. C. Kwan, Carol V. Robinson, Jane Clarke · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
34. The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential
    Mark F. van Delft, Grant Dewson · 2022 · Elsevier eBooks
35. The regulation of the apoptotic pore—An immunological tightrope walk
    Andreas Jenner, Ana J. García‐Sáez · 2024 · Advances in immunology
36. Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer
    Dean Anthony Fennell, Charles Swanton · 2012 · The EPMA Journal
37. Playing FullBAK
    Loren D. Walensky · 2013 · Cell Cycle
38. Targeting Antiapoptotic and Proapoptotic Proteins for Novel Chronic Lymphocytic Leukemia Therapeutics
    Christian Billard · 2014 · International Journal of Hematologic Oncology
39. Structural Perspectives on BCL-2 Family of Proteins
    Evripidis Gavathiotis · 2013 · Springer eBooks
40. Genome-wide identification and expression analysis of Bcl-2 gene family under low-temperature stress in tilapia (Oreochromis niloticus)
    Changgeng Yang, Meizi Wang, Hua Wen, Ming Jiang, Juan Tian, Xing Lü · 2020 · Israeli Journal of Aquaculture - Bamidgeh
41. Understanding Bcl-2 family interactions through computational modelling
    Benjamin Lansdell · 2012 · Minerva Access (University of Melbourne)
42. BH3-Only Proteins in Cancer and Apoptosis
    Fabio Ghiotto, Claudya Tenca, Franco Fais, Silvia Bruno · 2013 · Springer eBooks
43. Bak activators get in the groove
    Mitch Leslie · 2011 · The Journal of Cell Biology
44. Mecanismos moleculares mediadores da citoproteção de células beta pancreáticas induzidos por prolactina
    Rosangela Aparecida Wailemann Mansano · 2019 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
45. Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis
    Geetika Singh · 2020
46. Functional Precision Profiling: The Way Forward for Personalized Medicine
    Lyndsey Flanagan, Siobhan V. Glavey, Tríona Ní Chonghaile · 2021 · Journal of Clinical Haematology
47. References
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48. Supplementary Methods, Figure Legends, Tables 1 - 9 from Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy
    Andreas Ulrich Lindner, Caoimhín G. Concannon, Gerhardt J. Boukes, Mary D Cannon, Fabien Llambi, Deborah Ryan, Karen Boland, Joan Kehoe, Deborah A. McNamara, Frank Murray et al. · 2023
49. Supplementary Methods, Figure Legends, Tables 1 - 9 from Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy
    Andreas Ulrich Lindner, Caoimhín G. Concannon, Gerhardt J. Boukes, Mary D Cannon, Fabien Llambi, Deborah Ryan, Karen Boland, Joan Kehoe, Deborah A. McNamara, Frank Murray et al. · 2023
50. Understanding and tackling the resistance to BH3-mimetics in diffuse large B-Cell lymphoma
    Nahide Yildirim · 2024 · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)
51. CUL5 WSB2 uses BCL2 proteins as co-receptors to target BIM for degradation
    Wilhelm Vaysse-Zinkhöfer, Enya Marie Catherine Alcindor, Nicholas Garaffo, David Paul Toczyski · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
52. MNRR1 is required for Triple Negative Breast Cancer growth and metastasis and can be targeted by repurposed drugs
    Mrunal Sathe, Paige M. Minchella, Caleb Vegh, Mithra Modikuppam Dharmalingam, Vignesh Pasupathi, Yue Xi, Sagarika Rai, Mrunmayee Patil, Habiba Elshenawy, Sydney Rudolph et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
53. Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation
    Wilhelm Vaysse-Zinkhöfer, Enya Marie Catherine Alcindor, Nicholas Garaffo, David Paul Toczyski · 2026 · eLife
54. Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation
    Wilhelm Vaysse-Zinkhöfer, Enya Marie Catherine Alcindor, Nicholas Garaffo, David Paul Toczyski · 2026 · eLife
55. Analyse bioinformatique des protéines BCL-2 et développement de la base de connaissance dédiée, BCL2DB
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56. Molecular basis of BCL2L10/Nrh oncogenic activity in breast cancer
    Adrien Nougarède · 2016 · theses.fr (ABES)
57. Etude de la kinase PIM2 dans la différenciation terminale normale et tumorale des lymphocytes B en plasmocytes
    Marion Haas · 2023 · theses.fr (ABES)
58. Direct binding of the C-terminal sequences of Bim and Bak contributes to efficient Bak activation
    Dang Nguyen, Sabina Trebinjac, Tobias B. Beigl, Frank Eßmann, Kathryn M. Murphy, David William Andrews · 2026 · Cell Death and Differentiation
59. Viral infection activates the IRF1-BAK axis to drive mitochondria-derived inflammation
    Meidi Ye, Yifei Wang, Zhenqiong Guan, Zhenxing Zhou, Zihan Guan, Yulan Zhang, Shufen Li, Ke Peng · 2026 · Cell Reports