The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition
Open accessAbstract
Transforming growth factor β (TGF-β)–stimulated epithelial–mesenchymal transition (EMT) is an important developmental process that has also been implicated in increased cell invasion and metastatic potential of cancer cells. Expression of the focal adhesion protein Hic-5 has been shown to be up-regulated in epithelial cells in response to TGF-β. Herein, we demonstrate that TGF-β–induced Hic-5 up-regulation or ectopic expression of Hic-5 in normal MCF10A cells promoted increased extracellular matrix degradation and invasion through the formation of invadopodia. Hic-5 was tyrosine phosphorylated in an Src-dependent manner after TGF-β stimulation, and inhibition of Src activity or overexpression of a Y38/60F nonphosphorylatable mutant of Hic-5 inhibited matrix degradation and invasion. RhoC, but not RhoA, was also required for TGF-β– and Hic-5–induced matrix degradation. Hic-5 also induced matrix degradation, cell migration, and invasion in the absence of TGF-β via Rac1 regulation of p38 MAPK. These data identify Hic-5 as a critical mediator of TGF-β–stimulated invadopodia formation, cell migration, and invasion.
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Citations
Cites
TGF-β-induced epithelial to mesenchymal transition
Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804
Cited by
TGF-β signaling and epithelial–mesenchymal transition in cancer progression
Katsuno, Y., Lamouille, S., & Derynck, R. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835b6371 · Cited by 786
Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis
Leong, H. S., Robertson, A. E., Stoletov, K., Leith, S. J., Chin, C. A., Chien, A. E., Hague, M. N., Ablack, A., Carmine-Simmen, K., McPherson, V. A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.050 · Cited by 400
Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis
Eddy, R. J., Weidmann, M. D., Sharma, V. P., & Condeelis, J. S. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.03.003 · Cited by 375
Cellular and molecular mechanisms of MT1-MMP-dependent cancer cell invasion.
Castro-Castro, A., Marchesin, V., Monteiro, P., Lodillinsky, C., Rossé, C., & Chavrier, P. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125227 · Cited by 249
Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β
Tsubakihara, Y., & Moustakas, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113672 · Cited by 160
Metadata
- Authors
- Pignatelli, J., Tumbarello, D. A., Schmidt, R. P., & Turner, C. E.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-04-23
- Volume
- 197
- Issue
- 3
- Pages
- 421-437
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2127034758
- Cited by
- 162
- References
- 1
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pignatelli, J., Tumbarello, D. A., Schmidt, R. P., & Turner, C. E. (2012). Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition. Journal of Cell Biology. https://doi.org/10.1083/jcb.201108143
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