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AN ANALYSIS OF COLLAGEN SECRETION BY ESTABLISHED MOUSE FIBROBLAST LINES
Open accessAbstract
In vitro synthesis of collagen by established mouse fibroblast lines has been examined by electron microscopy. During rapid growth (log phase), when collagen could not be detected in the cultures, the cells lacked a well developed granular ergastoplasm and Golgi system. Upon cessation of growth (stationary phase), collagen accumulated in the cultures and the cells demonstrated highly developed granular and smooth ergastoplasm. Collagen appeared to be synthesized in the rough-surfaced endoplasmic reticulum and to be transported as a soluble protein to the cell surface by vesicular elements of the agranular ergastoplasm. Fusion of the limiting membranes of these vesicles with the cell membrane permitted the discharge of the soluble collagen into the extracellular space, where fibrils of two diameter distributions formed. The secretion of collagen is concluded to be of the merocrine type. Alternative theories of collagen secretion are discussed and the data for established lines compared with the results of other in vitro and in vivo studies of collagen fibrillogenesis.
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Cited by
Granulation tissue as a contractile organ
Gabbiani, G., Hirschel, B. J., Ryan, G. B., Statkov, P. R., & Majno, G. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.135.4.719 · Cited by 807
Siadat, S. M., & Ruberti, J. W. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.01.025 · Cited by 87
Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation
Heap, R. E., Marín-Rubio, J. L., Peltier, J., Heunis, T., Dannoura, A., Moore, A., & Trost, M. (2021) · Life Science Alliance · doi:10.26508/lsa.202000957 · Cited by 80
The differentiation of the dermis in the laboratory mouse
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Metadata
- Authors
- Goldberg, B., & Green, H.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1964-07-01
- Volume
- 22
- Issue
- 1
- Pages
- 227-258
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2066522430
- Cited by
- 347
- References
- 0
- FWCI
- 31.80
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: AN ANALYSIS OF COLLAGEN SECRETION BY ESTABLISHED MOUSE FIBROBLAST LINES. https://app.cochat.ai/papers/10.1083/jcb.22.1.227
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- Goldberg, B., & Green, H. (1964). AN ANALYSIS OF COLLAGEN SECRETION BY ESTABLISHED MOUSE FIBROBLAST LINES. The Journal of Cell Biology. https://doi.org/10.1083/jcb.22.1.227
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