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THE ENZYMATIC PREPARATION OF ISOLATED INTACT PARENCHYMAL CELLS FROM RAT LIVER
Open accessAbstract
Suspensions of isolated parenchymal cells were prepared from rat liver by incubation with collagenase and hyaluronidase followed by mechanical treatment. Utilization of 0.15% collagenase together with 0.15% hyaluronidase yielded adequate numbers of cells for experimental purposes. As shown by light and electron microscopy, approximately 75% of the isolated cells retain their structural integrity. The cell suspensions are capable of maintaining endogenous respiration in the presence of 1% albumin for periods of time up to 8 hr. These cell preparations consist almost entirely of parenchymal cells and offer a unique tissue preparation for the study of hepatic metabolism.
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Cited by
A modified method for the isolation of the plasma membrane from rat liver
Ray, T. K. (1970) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(70)90159-8 · Cited by 572
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
Brandon, E. F. A., Raap, C. D., Meijerman, I., Beijnen, J. H., & Schellens, J. H. M. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00128-5 · Cited by 567
Primary Hepatocyte Isolation and Cultures: Technical Aspects, Challenges and Advancements
Kaur, I., Vasudevan, A., Rawal, P., Tripathi, D. M., Ramakrishna, S., Kaur, S., & Sarin, S. K. (2023) · Bioengineering · doi:10.3390/bioengineering10020131 · Cited by 64
Green, C. J., Charlton, C. A., Wang, L.-M., Silva, M., Morten, K. J., & Hodson, L. (2017) · Cell and Tissue Banking · doi:10.1007/s10561-017-9641-6 · Cited by 43
Metadata
- Authors
- Howard, R. B., Christensen, A. K., Gibbs, F. A., & Pesch, L. A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1967-12-01
- Volume
- 35
- Issue
- 3
- Pages
- 675-684
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2129307251
- Cited by
- 224
- References
- 0
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: THE ENZYMATIC PREPARATION OF ISOLATED INTACT PARENCHYMAL CELLS FROM RAT LIVER. https://app.cochat.ai/papers/10.1083/jcb.35.3.675
- The paper
- Howard, R. B., Christensen, A. K., Gibbs, F. A., & Pesch, L. A. (1967). THE ENZYMATIC PREPARATION OF ISOLATED INTACT PARENCHYMAL CELLS FROM RAT LIVER. The Journal of Cell Biology. https://doi.org/10.1083/jcb.35.3.675
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
