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Staining of Tissue Sections for Electron Microscopy with Heavy Metals
Open accessAbstract
Heavy metals may be incorporated from solution into tissue sections for electron microscopy. The resulting increase in density of the tissue provides greatly enhanced contrast with minimal distortion. Relative densities of various structures are found to depend on the heavy metal ions present and on the conditions of staining. Certain hitherto unobserved details are revealed and some sort of specificity exists, although the factors involved are not yet understood.
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Citations
Cited by
A "MICROTUBULE" IN PLANT CELL FINE STRUCTURE
Ledbetter, M. C., & Porter, K. R. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.19.1.239 · Cited by 938
Capillarization of hepatic sinusoids in man
Schaffner, F., & Popper, H. (1963) · Gastroenterology · doi:10.1016/s0016-5085(63)80130-4 · Cited by 610
Germ Plasm and the Differentiation of the Germ Cell Line
Eddy, E. M. (1976) · International Review of Cytology · doi:10.1016/s0074-7696(08)60070-4 · Cited by 616
(1968) · PubMed Central · Cited by 332
Large-volume en-bloc staining for electron microscopy-based connectomics
Hua, Y., Laserstein, P., & Helmstaedter, M. (2015) · Nature Communications · doi:10.1038/ncomms8923 · Cited by 328
Metadata
- Authors
- Watson, M. L.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1958-07-25
- Volume
- 4
- Issue
- 4
- Pages
- 475-478
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2034912738
- Cited by
- 4,115
- References
- 0
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Staining of Tissue Sections for Electron Microscopy with Heavy Metals. https://app.cochat.ai/papers/10.1083/jcb.4.4.475
- The paper
- Watson, M. L. (1958). Staining of Tissue Sections for Electron Microscopy with Heavy Metals. The Journal of Cell Biology. https://doi.org/10.1083/jcb.4.4.475
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
