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Distribution of binding sites for human chorionic gonadotropin in the preovulatory follicle of the rat.
Open accessAbstract
The distribution of binding sites for human chorionic gonadotropin (hCG) in the preovulatory follicle was studied by autoradiography. An ovulatory dose (10 IU/rat) of [125I]hCG (1.4 muCi/IU) was administered intravenously, and large Graafian follicles were isolated 3 h later by microdissection. Injection of excess unlabeled hCG (500 IU/rat) prevented uptake of radioactivity by the follicle, indicating that binding of iodinated hormone was confined to specific and saturable receptor sites. The density of bound hormone molecules was highest in the theca interna and in three to four layers of mural granulosa cells adjacent to the basement membrane; labeling was chiefly associated with the cell borders. No significant binding could be detected either on the oocyte or on the cumulus cells surrounding the oocyte. We therefore suggest that the induction of ovum maturation does not require attachment of the hormone to the oocyte itself or to follicle cells in its immediate vicinity.
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Citations
Cited by
Oocyte control of ovarian follicular development and function in mammals
Eppig, J. J. (2001) · Reproduction · doi:10.1530/rep.0.1220829 · Cited by 1,021
Steroidogenic enzymes: Structure, function, and role in regulation of steroid hormone biosynthesis
Hanukoglu, I. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90307-5 · Cited by 554
Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte
Norris, R. P., Ratzan, W. J., Freudzon, M., Mehlmann, L. M., Krall, J., Movsesian, M. A., Wang, H., Ke, H., Nikolaev, V. O., & Jaffe, L. A. (2009) · Development · doi:10.1242/dev.035238 · Cited by 516
Molecular mechanisms of ovulation: co-ordination through the cumulus complex
Russell, D. L., & Robker, R. L. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml062 · Cited by 431
Schultz, R. M., Montgomery, R. R., & Belanoff, J. R. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90085-4 · Cited by 419
Metadata
- Authors
- Amsterdam, A., Koch, Y., Lieberman, M. E., & Lindner, H. R.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1975-12-01
- Volume
- 67
- Issue
- 3
- Pages
- 894-900
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2081104479
- Cited by
- 221
- References
- 0
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Amsterdam, A., Koch, Y., Lieberman, M. E., & Lindner, H. R. (1975). Distribution of binding sites for human chorionic gonadotropin in the preovulatory follicle of the rat. The Journal of cell biology. https://doi.org/10.1083/jcb.67.3.894
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
