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THE LOCALIZATION OF ENZYME ACTIVITIES IN THE RAT BRAIN
Abstract
Studies with rat brain illustrate the usefulness of formol-calcium-fixed tissue for studying both enzymatic "chemoarchitectonics" and intracellular organelles. Unembedded frozen sections and polyvinyl alcohol-embedded sections may be used to demonstrate the activities of DPNH-tetrazolium reductase localized in mitochondria and ergastoplasm, TPNH-tetrazolium reductase localized in mitochondria, ATPase (and/or apyrase or ADPase) in cell membranes, and acid phosphatase in lysosomes.1 Among the observations recorded are: (1) the presence of lysosomes in all cells of the brain; (2) the presence of numerous large lysosomes near the nuclei of capillary endothelial cells; (3) a polarized arrangement of large lysosomes in epithelial cells of the ependyma and choroid plexus; (4) the presence of ATPase activity in the cell membranes of some neurons; (5) the presence of either an apyrase or combination of ATPase and ADPase in the cell membranes of neuroglia and capillaries; (6) the presence of both DPNH- and TPNH-tetrazolium reductase activities in neuroglia; (7) the presence of DPNH- and TPNH-tetrazolium reductase activities in mitochondria and of DPNH-tetrazolium reductase activity in Nissl substance. The possible functional significance of these localizations is briefly discussed, as is their relation to "quantitative histochemistry" data available in the literature.
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The great majority of the total pool of lysosomes in neurons is localized in the somatodendritic compartment.
“the great majority of the total pool of lysosomes in neurons is localized in the somatodendritic compartment (Becker et al., 1960)”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Becker et al., 1960
The figure captions (p. 654) describe numerous lysosomes in neuronal cell bodies and dendrites, and the Results (p. 657) say lysosomes are readily seen in dendrites. But the paper says their presence in axons is difficult to establish and does not determine what fraction of the total neuronal lysosome pool is somatodendritic. (LLM, conf=0.86)
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TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles
Rudnik, S., Li, C. H., Gottschling, D.-C., Veh, A., Barbosa, D. J., Richter, J., Stroobants, S., Schuster, B., Beck, I. M., Sedlack, R., et al. (2026) · doi:10.64898/2026.10.27.762112
Metadata
- Authors
- Becker, N. H., Goldfischer, S., Shin, W.-Y., & Novikoff, A. B.
- Affiliations
- From the Department of Pathology, Albert Einstein College of Medicine, Yeshiva University, New York.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1960-12-01
- Volume
- 8
- Issue
- 3
- Pages
- 649-663
- ISSN
- 1540-8140
- 0021-9525
- PMC
- PMC2224959
- Cited by
- 84
- References
- 0
- Language
- en
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