The DOI matches its Crossref record.
MITOCHONDRIAL LOCALIZATION OF OXIDATIVE ENZYMES: STAINING RESULTS WITH TWO TETRAZOLIUM SALTS
Open accessAbstract
A comparison is made of the staining results obtained with Nitro-BT and MTT-Co++ as acceptors when DPNH is the substrate in frozen sections of cold formol-calcium-fixed rat kidney (normal and following ligation of the blood vessels) and human liver containing lipofuscin granules. The kidney results are evaluated in terms of mitochondrial morphology seen after classical mitochondrial stains and in electron micrographs. It is concluded that, except for formazan deposition on lipid-aqueous interfaces, Nitro-BT staining indicates the intracellular localization of oxidative enzymes, at least at the level of light microscopy. In contrast, the use of MTT-Co++ is not reliable for such intracellular localizations. The deposition of the formazan of MTT-Co++ is determined in large part by physicochemical factors other than enzyme localization. Despite marked abnormalities of the mitochondria in cells of the ligated kidney, MTT-Co++ formazan is generally deposited in the same dotlike fashion as in cells of normal kidney.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Biochemical Adaptations in Muscle
Holloszy, J. O. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96046-1 · Cited by 1,517
Muscle fiber type composition of the rat hindlimb
Armstrong, R. B., & Phelps, R. O. (1984) · American Journal of Anatomy · doi:10.1002/aja.1001710303 · Cited by 1,015
Skeletal Muscle Adaptability: Significance for Metabolism and Performance
Saltin, B., & Gollnick, P. D. (1983) · Comprehensive Physiology · doi:10.1002/cphy.cp100119 · Cited by 890
Eccentric exercise-induced injury to rat skeletal muscle
Armstrong, R. B., Ogilvie, R. W., & Schwane, J. A. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.54.1.80 · Cited by 772
Skeletal muscle enzymes and fiber composition in male and female track athletes
Costill, D. L., Daniels, J., Evans, W., Fink, W., Krahenbuhl, G., & Saltin, B. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.40.2.149 · Cited by 699
Metadata
- Authors
- Novikoff, A. B., Shin, W.-Y., & Drucker, J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1961-01-01
- Volume
- 9
- Issue
- 1
- Pages
- 47-61
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1983625376
- Cited by
- 612
- References
- 0
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: MITOCHONDRIAL LOCALIZATION OF OXIDATIVE ENZYMES: STAINING RESULTS WITH TWO TETRAZOLIUM SALTS. https://app.cochat.ai/papers/10.1083/jcb.9.1.47
- The paper
- Novikoff, A. B., Shin, W.-Y., & Drucker, J. (1961). MITOCHONDRIAL LOCALIZATION OF OXIDATIVE ENZYMES: STAINING RESULTS WITH TWO TETRAZOLIUM SALTS. The Journal of Cell Biology. https://doi.org/10.1083/jcb.9.1.47
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
