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Identity and Origin of the ATPase activity associated with neuronal microtubules. I. The ATPase activity is associated with membrane vesicles.
Open accessAbstract
Microtubule protein purified from brain tissue by cycles of in vitro assembly-disassembly contains ATPase activity that has been postulated to be associated with microtubule-associated proteins (MAPs) and therefore significant for studies of microtubule-dependent motility. In this paper we demonstrate that greater than 90% of the ATPase activity is particulate in nature and may be derived from contaminating membrane vesicles. We also show that the MAPs (MAP-1, MAP-2, and tau factors) and other high molecular weight polypeptides do not contain significant amounts of ATPase activity. These findings do not support the concept of "brain dynein" or of MAPs with ATPase activity.
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“but attempts to identify dynein in neural tissue, where organelle movements are common, have been unsuccessful (Murphy et al., 1983).”
From Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility (1985) · cites this paper as Murphy et al., 1983
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Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Metadata
- Authors
- Murphy, D. B., Hiebsch, R. R., & Wallis, K. T.
- Affiliations
- Johns Hopkins University (US)
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1983-05-01
- Volume
- 96
- Issue
- 5
- Pages
- 1298-1305
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2112664
- OpenAlex
- W2031858867
- Cited by
- 26
- References
- 0
- Citations by year
- 2025: 1
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Keywords
- ATPase activity, neuronal microtubules, microtubule-associated proteins, MAP1, MAP2, tau protein, membrane vesicles
- MeSH terms
- Adenosine Triphosphatases, Animals, Centrifugation, Density Gradient, Chromatography, Gel, Dyneins, Male, Microscopy, Electron, Microtubule-Associated Proteins, Microtubules, Neurons, Proteins, Swine
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