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DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE
Open accessAbstract
With an immunofluorescent technique involving the use of serum of hamsters with SV40 tumors, nuclear fluorescence was detected in each of five cell lines, derived from four mammalian species, transformed by SV40 virus. Essentially all nuclei, including those of multinuclear cells, were fluorescent-stainable. Serum of hamsters bearing SV40 tumors was also found to give nuclear fluorescence in susceptible cells (AGMK or BSC-1) acutely infected with SV40 virus. These findings provide further evidence that cellular incorporation of the SV40 viral genome, with partial expression of the genome by synthesis of at least one virus-specific antigen, is an integral property of all SV40 transformed cells.
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Citations
Cited by
Function of simian virus 40 gene A in transforming infection
Tegtmeyer, P. (1975) · Journal of Virology · doi:10.1128/jvi.15.3.613-618.1975 · Cited by 431
Saxton, R. E., Irie, R. F., Ferrone, S., Pellegrino, M. A., & Morton, D. L. (1978) · International Journal of Cancer · doi:10.1002/ijc.2910210308 · Cited by 27
Metadata
- Authors
- Pope, J. H., & Rowe, W. P.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1964-08-01
- Volume
- 120
- Issue
- 2
- Pages
- 121-128
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2008107181
- Cited by
- 420
- References
- 0
- FWCI
- 41.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE. https://app.cochat.ai/papers/10.1084/jem.120.2.121
- The paper
- Pope, J. H., & Rowe, W. P. (1964). DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.120.2.121
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.