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PROPERTIES OF ANTIBODIES CYTOPHILIC FOR MACROPHAGES
Open accessAbstract
Cytophilic activity for macrophages was shown to be a property possessed by most, if not all, of the complement binding 7S γ2-population of guinea pig antibodies. Cytophilic antibodies were also demonstrated in rabbit and mouse antisera to sheep red cells. While each species antibody best sensitized homologous macrophages, cross species sensitization was also observed. The binding site for macrophages resides on the Fc fragment, therefore, on the H chains, and is destroyed by pepsin hydrolysis or reduction and alkylation. The binding reaction is reversible with a high rate of dissociation at 37°C. Cytophilic activity is not complement dependent, and was shown to be that property of opsonizing antibody which provides the receptors that permit the binding of the antibody to the macrophage cell membrane in preparation for phagocytosis.
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Citations
Cited by
Structure and Function of Human and Murine Receptors for IgG
Unkeless, J. C., Scigliano, E., & Freedman, V. H. (1988) · Annual Review of Immunology · doi:10.1146/annurev.iy.06.040188.001343 · Cited by 470
The Structure and Function of Monocytes and Macrophages
Cohn, Z. A. (1968) · Advances in Immunology · doi:10.1016/s0065-2776(08)60443-5 · Cited by 269
In Vitro Approaches to the Mechanism of Cell-Mediated Immune Reactions
Bloom, B. R. (1971) · Advances in Immunology · doi:10.1016/s0065-2776(08)60184-4 · Cited by 253
Distinct development and functions of resident and recruited liver Kupffer cells/macrophages
Ikarashi, M., Nakashima, H., Kinoshita, M., Sato, A., Nakashima, M., Miyazaki, H., Nishiyama, K., Yamamoto, J., & Seki, S. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313144 · Cited by 132
Metadata
- Authors
- Berken, A., & Benacerraf, B.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1966-01-01
- Volume
- 123
- Issue
- 1
- Pages
- 119-144
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2086695584
- Cited by
- 482
- References
- 0
- FWCI
- 39.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: PROPERTIES OF ANTIBODIES CYTOPHILIC FOR MACROPHAGES. https://app.cochat.ai/papers/10.1084/jem.123.1.119
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- Berken, A., & Benacerraf, B. (1966). PROPERTIES OF ANTIBODIES CYTOPHILIC FOR MACROPHAGES. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.123.1.119
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
