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THE REACTION MECHANISM OF ß1C-GLOBULIN (C'3) IN IMMUNE HEMOLYSIS
Open accessAbstract
During immune hemolysis by human complement, C'3 (ß1C-globulin) becomes physically attached to the erythrocyte membrane. Binding of C'3 was found to be mediated by cell-bound, activated C'2 and to have the characteristics of an enzymatic reaction. A single C'4,2a site on the cell surface effected the binding of several hundred molecules of C'3 if the latter was provided in excess. The accumulation of hemolytically inactive, physicochemically altered C'3 in the fluid phase was found to be an inherent feature of the process of C'3 binding. It is postulated that C'4,2a activates C'3 for its subsequent reaction with cell membrane receptors. Antierythrocyte antibody did not play an essential role in C'3 uptake; C'3 could be bound to erythrocyte-C'4,2a complexes which were entirely devoid of antibody. Cell-bound C'3 proved hemolytically active, the degree of hemolysis being proportional to the number of C'3 molecules per cell. Binding of a large number of C'3 molecules per cell was found to be a prerequisite for the production of the immune adherence phenomenon and for immune hemolysis.
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Citations
Cited by
Craddock, P. R., Fehr, J., Dalmasso, A. P., Brighan, K. L., & Jacob, H. S. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108710 · Cited by 991
Self-citationThird component of human complement: purification from plasma and physicochemical characterization
Tack, B. F., & Prahl, J. W. (1976) · Biochemistry · doi:10.1021/bi00665a028 · Cited by 516
Cochrane, C. G., & Müller-Eberhard, H. J. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.127.2.371 · Cited by 461
Self-citationMolecular Biology and Chemistry of the Alternative Pathway of Complement
Müller-Eberhard, H. J., & Schreiber, R. D. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60042-5 · Cited by 408
Interaction between the third complement protein and cell surface macromolecules.
Law, S. K., & Levine, R. P. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.2701 · Cited by 345
Metadata
- Authors
- Müller-Eberhard, H. J., Dalmasso, A. P., & Calcott, M. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1966-01-01
- Volume
- 123
- Issue
- 1
- Pages
- 33-54
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2167065708
- Cited by
- 244
- References
- 0
- FWCI
- 18.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE REACTION MECHANISM OF ß1C-GLOBULIN (C'3) IN IMMUNE HEMOLYSIS. https://app.cochat.ai/papers/10.1084/jem.123.1.33
- The paper
- Müller-Eberhard, H. J., Dalmasso, A. P., & Calcott, M. A. (1966). THE REACTION MECHANISM OF ß1C-GLOBULIN (C'3) IN IMMUNE HEMOLYSIS. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.123.1.33
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
