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Cited by 177

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IMMUNOPATHOLOGY OF NZB/BL MICE

Open access
Mellors, Robert C., Huang, Chen Ya·1966·The Journal of Experimental Medicine
DOI 10.1084/jem.124.6.1031
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Abstract

A filtrable agent separable from transplantable malignant lymphomas of NZB/Bl mice was capable, upon inoculation into preweanling NZB/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys—renal functional and structural changes qualitatively similar to those of spontaneous occurrence in older NZB/Bl mice. Viruslike particles with close resemblance to the typical "C" type murine oncogenic virus particles were identified by means of electron microscopy in NZB/Bl mouse tissues and cells, including malignant lymphoma cells, benign lymphoid cells of thymus and spleen, epithelial cells of renal tubules, and extracellular sites. The relevance of these observations, the first of their kind dealing with NZB/Bl mice, is discussed in relation to the several immunopathological disorders which characterize this strain of mice.

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Metadata

Authors
Mellors, R. C., & Huang, C. Y.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
1966-12-01
Volume
124
Issue
6
Pages
1031-1038
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.124.6.1031
OpenAlex
W2042172544
Cited by
177
References
0
FWCI
33.16
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: IMMUNOPATHOLOGY OF NZB/BL MICE. https://app.cochat.ai/papers/10.1084/jem.124.6.1031
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Mellors, R. C., & Huang, C. Y. (1966). IMMUNOPATHOLOGY OF NZB/BL MICE. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.124.6.1031

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.