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GLOMERULAR PERMEABILITY
Open accessAbstract
1. Glomerular permeability was studied by ultrastructural cytochemistry, using as protein tracers two intravenously injected peroxidases of differing molecular weight. 2. Horseradish peroxidase (molecular weight 40,000) passed rapidly through the endothelial fenestrae, across the basement membrane, and through the epithelial slits into the urinary space. Human myeloperoxidase (molecular weight 160,000 to 180,000) also passed rapidly through the endothelial fenestrae and across the basement membrane, but was impeded at the level of the epithelial slits. Both proteins were taken up in large amounts by the mesangial cells. 3. The present findings indicate that the epithelial slits are the primary filtration barrier responsible for the differential permeability to proteins of varying molecular size. 4. The observations also support the concept that an important function of the mesangial cells is the incorporation and disposal of glomerular filtration residues.
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Citations
Cited by
Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499
Sugimoto, H., Hamano, Y., Charytan, D., Cosgrove, D., Kieran, M., Sudhakar, A., & Kalluri, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300012200 · Cited by 538
Permselectivity of the glomerular capillary wall: III. Restricted transport of polyanions
Chang, R. L. S., Deen, W. M., Robertson, C. R., & Brenner, B. M. (1975) · Kidney International · doi:10.1038/ki.1975.104 · Cited by 386
Metabolism of Proinsulin, Insulin, and C-Peptide in the Rat
Katz, A. I., & Rubenstein, A. H. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107277 · Cited by 264
Stress stimulates transepithelial macromolecular uptake in rat jejunum
Kiliaan, A. J., Saunders, P. R., Bijlsma, P. B., Berin, M. C., Taminiau, J. A., Groot, J. A., & Perdue, M. H. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.5.g1037 · Cited by 223
Metadata
- Authors
- Graham, R. C., & Karnovsky, M. J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1966-12-01
- Volume
- 124
- Issue
- 6
- Pages
- 1123-1134
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2109656846
- Cited by
- 393
- References
- 0
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Graham, R. C., & Karnovsky, M. J. (1966). GLOMERULAR PERMEABILITY. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.124.6.1123
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
