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IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE
Open accessAbstract
A culture system for cell suspensions from mouse spleens has been described. The system provides adequate conditions for in vitro immunization on initial exposure to heterologous erythrocytes. The in vitro response closely parallels that observed in vivo with respect to size, early kinetics, antigen dose, and the inhibitory effect of passive antibody. The response of cultured cells differs in two respects from that seen in vivo. There is an increase in the ability to discriminate between different varieties of homologous erythrocytes and the in vitro response does not appear to be limited by whatever mechanisms regulate the in vivo response.
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Citations
Cited by
A Requirement for Two Cell Types for Antibody Formation in vitro
Mosier, D. E. (1967) · Science · doi:10.1126/science.158.3808.1573 · Cited by 608
Caldwell, C. C., Kojima, H., Lukashev, D., Armstrong, J., Farber, M., Apasov, S. G., & Sitkovsky, M. V. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6140 · Cited by 420
Genetics of the Antibody Response to Dextran in Mice
Blomberg, B., Geckeler, W. R., & Weigert, M. (1972) · Science · doi:10.1126/science.177.4044.178 · Cited by 342
The role of opioid receptors in immune system function
Eisenstein, T. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02904 · Cited by 286
In Vitro Approaches to the Mechanism of Cell-Mediated Immune Reactions
Bloom, B. R. (1971) · Advances in Immunology · doi:10.1016/s0065-2776(08)60184-4 · Cited by 253
Metadata
- Authors
- Mishell, R. I., & Dutton, R. W.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1967-09-01
- Volume
- 126
- Issue
- 3
- Pages
- 423-442
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1975649472
- Cited by
- 2,033
- References
- 0
- FWCI
- 26.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE. https://app.cochat.ai/papers/10.1084/jem.126.3.423
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- Mishell, R. I., & Dutton, R. W. (1967). IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.126.3.423
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
