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THE RENAL HANDLING OF HEMOGLOBIN
Open accessAbstract
The glomerular filtration of hemoglobin (α2ß2) was studied under conditions in which its dissociation into αß dimers was experimentally altered. Rats receiving hemoglobin treated with the sulfhydryl reagent bis(N-maleimidomethyl) ether (BME) showed a much lower renal excretion and prolonged plasma survival as compared with animals injected with untreated hemoglobin. Plasma disappearance was also prolonged in dogs receiving BME hemoglobin. Gel filtration data indicated that under physiological conditions, BME hemoglobin had impaired subunit dissociation. In addition, BME hemoglobin showed a very high oxygen affinity and a decreased rate of auto-oxidation. Glomerular filtration was enhanced under conditions which favor the dissociation of hemoglobin into dimers. Cat hemoglobin, which forms subunits much more extensively than canine hemoglobin, was excreted more readily by the rat kidney. The renal uptake of 59Fe hemoglobin injected intra-arterially into rabbits varied inversely with the concentration of the injected dose.
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Cited by
Riess, J. G. (2001) · Chemical Reviews · doi:10.1021/cr970143c · Cited by 773
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Fathollahipour, S., Patil, P. S., & Leipzig, N. D. (2018) · Cells Tissues Organs · doi:10.1159/000493162 · Cited by 101
Controlled oxygen delivery to power tissue regeneration
Zoneff, E., Wang, Y., Jackson, C., Smith, O., Duchi, S., Onofrillo, C., Farrugia, B., Moulton, S. E., Williams, R., Parish, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48719-x · Cited by 89
Metadata
- Authors
- Bunn, H. F., Esham, W. T., & Bull, R. W.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1969-05-01
- Volume
- 129
- Issue
- 5
- Pages
- 909-924
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2125570845
- Cited by
- 189
- References
- 0
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE RENAL HANDLING OF HEMOGLOBIN. https://app.cochat.ai/papers/10.1084/jem.129.5.909
- The paper
- Bunn, H. F., Esham, W. T., & Bull, R. W. (1969). THE RENAL HANDLING OF HEMOGLOBIN. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.129.5.909
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
