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ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN
Open accessAbstract
An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs. This enzyme is thermolabile, nondialyzable, and forms a vasoconstrictive material when incubated with renin plasma substrate at pH 7. A short lasting pressor activity was also found in brain extracts of dogs and rats. This activity was due to a substance identified by chemical and pharmacological tests as angiotensin. Countercurrent distribution of brain extracts of rats showed that 38% of the pressor activity corresponded to angiotensin II and the remainder to angiotensin I. A remarkable correlation was found between angiotensin and norepinphrine concentrations in different portions of the encephalon of the dog.
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Citations
Cited by
Cardiovascular Effects of Angiotensin Mediated by the Central Nervous System
FERRARIO, C. M., GILDENBERG, P. L., & MCCUBBIN, J. W. (1972) · Circulation Research · doi:10.1161/01.res.30.3.257 · Cited by 353
Fuxe, K., Ganten, D., Hökfelt, T., & Bolme, P. (1976) · Neuroscience Letters · doi:10.1016/0304-3940(76)90020-3 · Cited by 309
Adrenergic Facilitation by Angiotensin: Does it Serve a Physiological Function?
Zimmerman, B. G. (1981) · Clinical Science · doi:10.1042/cs0600343 · Cited by 255
Rabie, M. A., Abd El Fattah, M. A., Nassar, N. N., El-Abhar, H. S., & Abdallah, D. M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.047 · Cited by 90
Metadata
- Authors
- Fischer-Ferraro, C., Nahmod, V. E., Goldstein, D. J., & Finkielman, S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1971-02-01
- Volume
- 133
- Issue
- 2
- Pages
- 353-361
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2084150614
- Cited by
- 352
- References
- 0
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN. https://app.cochat.ai/papers/10.1084/jem.133.2.353
- The paper
- Fischer-Ferraro, C., Nahmod, V. E., Goldstein, D. J., & Finkielman, S. (1971). ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.133.2.353
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
