The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of tumor angiogenesis mediated by cartilage.
Open accessAbstract
Capillary proliferation induced by tumor is shown to be inhibited by neonatal scapular cartilage. Using the rabbit cornea as an assay, the cartilage implant decreased the rate of capillary growth, induced by tumor, by an average of 75%. Vascularization was prevented completely in 28% of tumors. The inhibitory effect of small cartilage implants operates over distances of up to 2.0 mm and displays a gradient from the cartilage source. The experiments suggest that the cartilage inhibitor does not antagonize tumor angiogenesis factor, but appears to inhibit capillary proliferation directly. The inhibitory material does not elicit an inflammatory response in either the rabbit cornea or in the chick chorioallantoic membrane. Thus with further purification, it may prove useful as a means of maintining tumor dormancy by "antiangiogenesis."
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Citations
Cites
SELF-REGULATION OF GROWTH IN THREE DIMENSIONS
Folkman, J., & Hochberg, M. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.138.4.745 · Cited by 829
Self-citation
Cited by
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis
Strieter, R. M., Polverini, P. J., Kunkel, S. L., Arenberg, D. A., Burdick, M. D., Kasper, J., Dzuiba, J., Van Damme, J., Walz, A., Marriott, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27348 · Cited by 1,222
Tumor interactions with the vasculature: angiogenesis and tumor metastasis
Blood, C. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(90)90014-r · Cited by 593
Protamine is an inhibitor of angiogenesis
Taylor, S., & Folkman, J. (1982) · Nature · doi:10.1038/297307a0 · Cited by 580
Self-citationNicolson, G. L. (1982) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(82)90020-8 · Cited by 560
Identification of an Inhibitor of Neovascularization from Cartilage
Moses, M. A., Sudhalter, J., & Langer, R. (1990) · Science · doi:10.1126/science.1694043 · Cited by 477
Metadata
- Authors
- Brem, H., & Folkman, J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1975-02-01
- Volume
- 141
- Issue
- 2
- Pages
- 427-439
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1997107937
- Cited by
- 359
- References
- 1
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brem, H., & Folkman, J. (1975). Inhibition of tumor angiogenesis mediated by cartilage. The Journal of experimental medicine. https://doi.org/10.1084/jem.141.2.427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
