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Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever.
Open accessAbstract
46% of sera from 30 children with rheumatic chorea showed IgG antibody reacting with neuronal cytoplasm of human caudate and subthalamic nuclei. The antibody was also detected in 14% of 50 children with active rheumatic carditis. 55 normal control sera, as well as 148 sera from a broad variety of other disease states showed a low prevalence (1.8-4.0%) of positive reactions. In rheumatic chorea the presence of anti-neuronal antibody appeared to correlate with severity and duration of clinical attacks. Antibody reacting with neuronal cytoplasm was completely removed by absorption with Group A streptococcal membranes or with isolated human neurons from caudate nucleus. Partial absorption of antibody was also recorded using Group A cell wall preparations but not with Group A carbohydrate. No absorption of positive reactions was seen with streptococcal Group D membranes or cell walls. In rheumatic chorea, anti-neuronal antibody appeared to represent cross-reaction with antigens shared by Group A streptococcal membranes.
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Cited by
Swedo, S. E., Leonard, H. L., Garvey, M., Mittleman, B., Allen, A. J., Perlmutter, S., Dow, S., Zamkoff, J., Dubbert, B. K., & Lougee, L. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.2.264 · Cited by 1,534
Perlmutter, S. J., Leitman, S. F., Garvey, M. A., Hamburger, S., Feldman, E., Leonard, H. L., & Swedo, S. E. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12297-3 · Cited by 556
High prevalence of obsessive–compulsive symptoms in patients with Sydenham's chorea
(1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.2.246 · Cited by 421
Bandelow, B., Baldwin, D., Abelli, M., Bolea-Alamanac, B., Bourin, M., Chamberlain, S. R., Cinosi, E., Davies, S., Domschke, K., Fineberg, N., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1190867 · Cited by 347
Brimberg, L., Benhar, I., Mascaro-Blanco, A., Alvarez, K., Lotan, D., Winter, C., Klein, J., Moses, A. E., Somnier, F. E., Leckman, J. F., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.56 · Cited by 202
Metadata
- Authors
- Husby, G., van de Rijn, I., Zabriskie, J. B., Abdin, Z. H., & Williams, R. C.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1976-10-01
- Volume
- 144
- Issue
- 4
- Pages
- 1094-1110
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2121468384
- Cited by
- 536
- References
- 0
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Husby, G., van de Rijn, I., Zabriskie, J. B., Abdin, Z. H., & Williams, R. C. (1976). Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. The Journal of experimental medicine. https://doi.org/10.1084/jem.144.4.1094
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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