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Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf.
Open accessAbstract
Structural variation in the second component of human complement was identified in about 4% of serum samples from random unrelated individuals of all the major races. Three forms of C2 have been identified by isoelectric focusing in polyacrylamide gel and development of patterns in agarose gel containing antibody-sensitized sheep red cells and C2-deficient serum: C2 C (common), C2 A (acidic), and C2 B (basic). The C2 variants were shown to be inherited as autosomal codominant traits, and suggestive evidence for close linkage between C2 and Bf was obtained.
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Cited by
A study of proteases and protease-inhibitor complexes in biological fluids
Granelli-Piperno, A., & Reich, E. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.148.1.223 · Cited by 803
Fleischnick, E., Raum, D., Alosco, S. M., Gerald, P. S., Yunis, E. J., Awdeh, Z. L., Granados, J., Crigler, J. F., Giles, C. M., & Alper, C. A. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92757-5 · Cited by 78
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Metadata
- Authors
- Alper, C. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1976-10-01
- Volume
- 144
- Issue
- 4
- Pages
- 1111-1115
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2130970849
- Cited by
- 238
- References
- 0
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Alper, C. A. (1976). Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf. The Journal of experimental medicine. https://doi.org/10.1084/jem.144.4.1111
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