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Arthritis in rats after systemic injection of streptococcal cells or cell walls.
Open accessAbstract
Further investigation of the biological properties of streptococcal cells and their components has produced a model of erosive synovitis in rats. A single intraperitoneal injection of an aqueous suspension of whole cell sonicate of group A streptococci into Sprague-Dawley rats induced an acute arthritis which evolved into a prolonged inflammatory process characterized by several complete or partial remissions, joint deformity, and ankylosis. The toxic moiety is a peptidoglycan-polysaccharide fragment of the cell wall which persists in tissue. Histologic features of the arthritis include an acute exudative phase followed by an erosive synovitis that leads to destruction of cartilage and subchondral bone and fibrous ankylosis of the joints. The arthropathic properties of whole cell sonicates of several species of streptococci are compared along with studies of the ability of heat-killed, whole cells of groups A, B, and C streptococci to induce arthritis in rats. Whole cells induce arthritis after a latent period of 57-120 days when group A cells are injected and 7-10 days when group B cells are tested.
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Citations
Cited by
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Pierer, M., Rethage, J., Seibl, R., Lauener, R., Brentano, F., Wagner, U., Hantzschel, H., Michel, B. A., Gay, R. E., Gay, S., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1256 · Cited by 273
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Metadata
- Authors
- Cromartie, W. J., Craddock, J. G., Schwab, J. H., Anderle, S. K., & Yang, C. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1977-12-01
- Volume
- 146
- Issue
- 6
- Pages
- 1585-1602
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1964756939
- Cited by
- 438
- References
- 0
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cromartie, W. J., Craddock, J. G., Schwab, J. H., Anderle, S. K., & Yang, C. H. (1977). Arthritis in rats after systemic injection of streptococcal cells or cell walls. The Journal of experimental medicine. https://doi.org/10.1084/jem.146.6.1585
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
