The DOI matches its Crossref record.
Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.
Abstract
Small amounts of PGE inhibit mitogen-induced [3H]thymidine incorporation in human peripheral lymphocytes. The 50% inhibitory concentration is approximately 10(-7) M, and this is reduced to approximately 10(-8) M when endogenous PGE production is blocked. PGE inhibits PHA- and Con A-stimulated cultures much better than PWM cultures, suggesting a differential effect of PGE on T-cell vs. B-cell function. In vitro blockade of PG synthesis results in approximately 50% increase in [3H]thymidine incorporation in PHA cultures. PGE is produced endogenously in PHA cultures by glass adherent suppressor cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Since PGE2 has been shown to inhibit both B and T cell differentiation and activation48,49, this could result in a reduced ability to clear viral infections.”
From The effect of smoking on chronic inflammation, immune function and blood cell composition (2020) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
CAR T Cell Therapy for Solid Tumors
Newick, K., O'Brien, S., Moon, E., & Albelda, S. M. (2017) · Annual Review of Medicine · doi:10.1146/annurev-med-062315-120245 · Cited by 909
The effect of smoking on chronic inflammation, immune function and blood cell composition
Elisia, I., Lam, V., Cho, B., Hay, M., Li, M. Y., Yeung, M., Bu, L., Jia, W., Norton, N., Lam, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76556-7 · Cited by 263
Trebble, T. M., Wootton, S. A., Miles, E. A., Mullee, M., Arden, N. K., Ballinger, A. B., Stroud, M. A., Burdge, G. C., & Calder, P. C. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.376 · Cited by 179
Age-associated alterations in immune function and inflammation
Lewis, E. D., Wu, D., & Meydani, S. N. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110576 · Cited by 111
Tamir, A., Granot, Y., & Isakov, N. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1514 · Cited by 79
Metadata
- Authors
- Goodwin, J. S., Bankhurst, A. D., & Messner, R. P.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1977-12-01
- Volume
- 146
- Issue
- 6
- Pages
- 1719-1734
- ISSN
- 0022-1007
- 1540-9538
- Cited by
- 635
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. https://app.cochat.ai/papers/10.1084/jem.146.6.1719
- The paper
- Goodwin, J. S., Bankhurst, A. D., & Messner, R. P. (1977). Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. The Journal of experimental medicine. https://doi.org/10.1084/jem.146.6.1719
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
