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Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice.
Open accessAbstract
NZB/NZW F1 mice of both sexes were castrated at 2 wk of age and implanted subcutaneously with silastic tubes containing either 5-alpha-dihydrotestosterone or estradiol-17-beta. Mice receiving androgen showed improved survival, reduced anti-nucleic acid antibodies, or less evidence of glomerulonephritis as determined by light, immunofluorescent, and electron microscopy. By contrast, opposite effects were observed in castrated mice receiving estrogen. Intact male NZB/NZW F1 mice received androgen implants at 8 mo, an age when they develop an accelerated autoimmune disease associated with a decline in serum testosterone concentration. Such treated mice had improved survival and reduced concentrations of antibodies to DNA and to polyadenylic acid (Poly A). Prepubertal castration of male NZB/NZW F1 mice results in an earlier appearance of IgG antibodies to Poly A. This effect of castration was prevented if neonatal thymectomy was also performed.
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Citations
Cited by
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Suppressive effects of androgens on the immune system
Trigunaite, A., Dimo, J., & Jørgensen, T. N. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.004 · Cited by 551
Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis
Hewagama, A., Patel, D., Yarlagadda, S., Strickland, F. M., & Richardson, B. C. (2009) · Genes & Immunity · doi:10.1038/gene.2009.12 · Cited by 311
Augmentation of T cell levels and responses induced by androgen deprivation
Roden, A. C., Moser, M. T., Tri, S. D., Mercader, M., Kuntz, S. M., Dong, H., Hurwitz, A. A., McKean, D. J., Celis, E., Leibovich, B. C., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6098 · Cited by 276
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Metadata
- Authors
- Roubinian, J. R., Talal, N., Greenspan, J. S., Goodman, J. R., & Siiteri, P. K.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1978-06-01
- Volume
- 147
- Issue
- 6
- Pages
- 1568-1583
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2117355775
- Cited by
- 636
- References
- 0
- FWCI
- 21.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. https://app.cochat.ai/papers/10.1084/jem.147.6.1568
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- Roubinian, J. R., Talal, N., Greenspan, J. S., Goodman, J. R., & Siiteri, P. K. (1978). Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. The Journal of experimental medicine. https://doi.org/10.1084/jem.147.6.1568
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