The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens.
Open accessAbstract
We have studied the modulation of Ia-like antigens on the surface membrane of human T cells responding in a one-way mixed leukocyte culture. A heterologous antiserum, (anti-p23,30), which is specific to HLA-D-related antigens and which is unreactive with normal peripheral T cells or thymocytes, was found to bind significantly to all T cells transformed in mixed leukocyte culture (MLC) as determined by indirect immunofluorescence on a fluorescence-activated cell sorter 1. Furthermore, cytotoxic T cells responsible for cell-mediated lympholysis were shown to react with anti-p23,30, whereas their unactivated progenitors did not. Immunoprecipitation and sodium dodecyl sulfate polyacrylamide gel electrophoresis of a radioactive 29,000 and 34,000 dalton complex from MLC-primed T cells labeled with [35S]methionine indicated that allosensitized T cells synthesized these HLA-D-related antigens.
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Citations
Cites
Kessler, S. W. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.115.6.1617 · Cited by 2,915
Polypeptides of the tail fibres of bacteriophage T4
King, J., & Laemmli, U. K. (1971) · Journal of Molecular Biology · doi:10.1016/0022-2836(71)90148-3 · Cited by 957
Distribution of Ia-like molecules on the surface of normal and leukemic human cells.
Schlossman, S. F., Chess, L., Humphreys, R. E., & Strominger, J. L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1288 · Cited by 319
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Cited by
Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men
Holling, T. M., Schooten, E., & van Den Elsen, P. J. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.01.005 · Cited by 334
Metadata
- Authors
- Evans, R. L., Faldetta, T. J., Humphreys, R. E., Pratt, D. M., Yunis, E. J., & Schlossman, S. F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1978-11-01
- Volume
- 148
- Issue
- 5
- Pages
- 1440-1445
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2165271672
- Cited by
- 365
- References
- 3
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. https://app.cochat.ai/papers/10.1084/jem.148.5.1440
- The paper
- Evans, R. L., Faldetta, T. J., Humphreys, R. E., Pratt, D. M., Yunis, E. J., & Schlossman, S. F. (1978). Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. The Journal of experimental medicine. https://doi.org/10.1084/jem.148.5.1440
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
