The DOI matches its Crossref record.
Endothelial injury in scleroderma.
Open accessAbstract
Functional and structural vascular lesions have been observed in the organs involved in scleroderma. The etiology of these vascular changes is poorly understood. The ability to isolate, characterize, and maintain endothelial cells in vitro provides a target cell population to study endothelial damage in scleroderma. The present report describes the effect of scleroderma serum on endothelial, smooth muscle, and fibroblast cell types. Sera from patients with scleroderma (31/52) and Raynaud's syndrome (11/19) contain cytotoxic activity, specific for endothelial cells, which is nondialyzable, heat-stable, and elutes with albumin on gel-filtration chromatography.
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Citations
Cited by
Systemic sclerosis: a prototypic multisystem fibrotic disorder
Varga, J., & Abraham, D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31139 · Cited by 1,163
Sequential dermal microvascular and perivascular changes in the development of scleroderma
Prescott, R. J., Freemont, A. J., Jones, C. J. P., Hoyland, J., & Fielding, P. (1992) · The Journal of Pathology · doi:10.1002/path.1711660307 · Cited by 391
The CREST syndrome: A distinct serologic entity with anticentromere antibodies
Fritzler, M. J., Kinsella, T. D., & Garbutt, E. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90462-3 · Cited by 366
On Scleroderma: Mast Cells, Endothelial Cells, and Fibroblasts
Claman, H. N. (1989) · JAMA · doi:10.1001/jama.1989.03430090068035 · Cited by 112
Metadata
- Authors
- Kahaleh, M. B., Sherer, G. K., & LeRoy, E. C.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1979-06-01
- Volume
- 149
- Issue
- 6
- Pages
- 1326-1335
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2152089397
- Cited by
- 286
- References
- 0
- FWCI
- 16.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Kahaleh, M. B., Sherer, G. K., & LeRoy, E. C. (1979). Endothelial injury in scleroderma. The Journal of experimental medicine. https://doi.org/10.1084/jem.149.6.1326
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
