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Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment.

Open access
Postlethwaite, A E, Keski-Oja, J, Balian, G, Kang, A H·1981·The Journal of experimental medicine

Abstract

Plasma and cell-derived fibronectin are potent chemoattractants for human dermal fibroblasts in vitro. The chemotactic property of fibronectin resides in a major 140,000-mol wt non-gelatin-binding fragment of the native molecule. Human monocytes and neutrophils do not recognize fibronectin as a chemotactic stimulus. These findings suggest that fibronectin and perhaps certain fragments of fibronectin may function in vivo as a specific chemoattractant for fibroblasts and could, therefore, induce directional migration of fibroblasts to sites of tissue injury, remodeling or morphogenesis.

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Metadata

Authors
Postlethwaite, A. E., Keski-Oja, J., Balian, G., & Kang, A. H.
Venue
The Journal of experimental medicine
Published
1981-02-01
Volume
153
Issue
2
Pages
494-499
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2104606637
Cited by
367
References
0
FWCI
16.60
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment. https://app.cochat.ai/papers/10.1084/jem.153.2.494
The paper
Postlethwaite, A. E., Keski-Oja, J., Balian, G., & Kang, A. H. (1981). Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment. The Journal of experimental medicine. https://doi.org/10.1084/jem.153.2.494

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.