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Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.
Open accessAbstract
The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.
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Citations
Cited by
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Xu, Y., Ma, M., Ippolito, G. C., Schroeder, H. W., Carroll, M. C., & Volanakis, J. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261428398 · Cited by 198
Type I interferons protect neonates from acute inflammation through interleukin 10–producing B cells
Zhang, X., Deriaud, E., Jiao, X., Braun, D., Leclerc, C., & Lo-Man, R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062013 · Cited by 150
Pineda, M. A., Lumb, F., Harnett, M. M., & Harnett, W. (2014) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2014.03.003 · Cited by 88
Metadata
- Authors
- Briles, D. E., Nahm, M., Schroer, K., Davie, J., Baker, P., Kearney, J., & Barletta, R.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-03-01
- Volume
- 153
- Issue
- 3
- Pages
- 694-705
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2103516617
- Cited by
- 464
- References
- 0
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Briles, D. E., Nahm, M., Schroer, K., Davie, J., Baker, P., Kearney, J., & Barletta, R. (1981). Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae. The Journal of experimental medicine. https://doi.org/10.1084/jem.153.3.694
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
