The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Induction of anterior chamber-associated immune deviation requires an intact, functional spleen.
Open accessAbstract
Anterior chamber-associated immune deviation (ACAID) expresses itself in BALB/c mice inoculated intracamerally with P815 cells in three ways: progressive growth of the tumor within the eye, transient growth of P815 cells injected subcutaneously, and prolonged acceptance of DBA/2 skin allografts. The spleen was found to play a crucial role in the development of ACAID. Splenectomized animals bearing intracameral P815 tumors reject DBA/2 skin grafts in an accelerated manner. A functioning spleen was required during the first 10 d after intracameral inoculation of P815 cells, but not thereafter. Reconstitution experiments revealed that the spleen's ability to support the induction of ACAID depends partly upon its constituent lymphoid cells, but also upon either a stromal component or a unique architectural arrangement that can only be restored with splenic fragments. The data hold promise that therapeutic protocols using appropriately timed splenectomy and specific immunization can be devised to induce hosts bearing intraocular tumors to mount an immune response sufficiently vigorous to destroy the tumor within the eye, and sufficiently precise to preserve the functional and anatomic integrity of the eye.
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Citations
Cites
Immunology and immunopathology of the eye
Silverstein, A. M., & O’Connor, G. R. (1979) · Medical Entomology and Zoology · Cited by 245
Kaplan, H. J., & Streilein, J. W. (1977) · PubMed · Cited by 208
Self-citationDeviant immune responses to allogeneic tumors injected intracamerally and subcutaneously in mice.
Niederkorn, J. Y., Streilein, J. W., & Shadduck, J. A. (1981) · PubMed · Cited by 160
Self-citationStreilein, J. W., Niederkorn, J. Y., & Shadduck, J. A. (1980) · The Journal of Experimental Medicine · doi:10.1084/jem.152.4.1121 · Cited by 134
Self-citationKaplan, H. J., & Streilein, J. W. (1978) · PubMed · Cited by 94
Self-citationImmunogenetic basis for immunologic privilege in the anterior chamber of the eye
Niederkorn, J. Y., Shadduck, J. A., & Streilein, J. W. (1981) · Immunogenetics · doi:10.1007/bf00350789 · Cited by 33
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Cited by
Ayres, J. S., & Schneider, D. S. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075030 · Cited by 475
See no evil, hear no evil, do no evil: the lessons of immune privilege
Niederkorn, J. Y. (2006) · Nature Immunology · doi:10.1038/ni1328 · Cited by 447
Self-citationCD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance
Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R., & Ferguson, T. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80305-2 · Cited by 382
Cultured Human Corneal Endothelial Cell Transplantation with a Collagen Sheet in a Rabbit Model
Mimura, T., Yamagami, S., Yokoo, S., Usui, T., Tanaka, K., Hattori, S., Irie, S., Miyata, K., Araie, M., & Amano, S. (2004) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-1174 · Cited by 277
STEIN-STREILEIN, J., & STREILEIN, J. W. (2002) · International Reviews of Immunology · doi:10.1080/08830180212066 · Cited by 218
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Metadata
- Authors
- Streilein, J. W., & Niederkorn, J. Y.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-05-01
- Volume
- 153
- Issue
- 5
- Pages
- 1058-1067
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2127749729
- Cited by
- 256
- References
- 6
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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