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Studies of endotoxin-induced decrease in lipoprotein lipase activity.
Open accessAbstract
A variety of invasive stimuli have been shown to induce hyperlipidemia due to impaired removal of triglyceride from the circulation. The mechanism by which endotoxin induces a deficiency in the activity of the key enzyme of triglyceride metabolism, lipoprotein lipase (LPL), has been studied. In C3H/HeN (endotoxin-sensitive) mice, LPL activity in adipose tissue was markedly suppressed 16 h after endotoxin administration. In contrast, the endotoxin-resistant C3H/HeJ mice were less sensitive to the suppressive effect of endotoxin on LPL activity. After endotoxin administration, a transferable factor had been detected in the blood of C3H/HeN mice 2 h after the injection of endotoxin that causes a suppression of adipose tissue LPL activity in C3H/HeJ mice as well as in C3H/HeN mice. Conditioned medium from the cultures of peritoneal exudate cells of C3H/HeN mice incubated in endotoxin also suppresses adipose tissue LPL in C3H/HeJ mice. These studies demonstrate that exudate cells produce a humoral factor in response to endotoxin, which suppresses adipose tissue LPL.
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Cited by
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Ruan, H., & Lodish, H. F. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00052-2 · Cited by 541
Sherry, B., & Cerami, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1269 · Cited by 432
Self-citationBreder, C. D., Hazuka, C., Ghayur, T., Klug, C., Huginin, M., Yasuda, K., Teng, M., & Saper, C. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11393 · Cited by 226
Metadata
- Authors
- Kawakami, M., & Cerami, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-09-01
- Volume
- 154
- Issue
- 3
- Pages
- 631-639
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2033202922
- Cited by
- 327
- References
- 0
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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