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Cited by 687

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Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

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Wooley, P H, Luthra, H S, Stuart, J M, David, C S·1981·The Journal of experimental medicine

Abstract

A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.

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Metadata

Authors
Wooley, P. H., Luthra, H. S., Stuart, J. M., & David, C. S.
Venue
The Journal of experimental medicine
Published
1981-09-01
Volume
154
Issue
3
Pages
688-700
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2040937120
Cited by
687
References
0
FWCI
13.76
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. https://app.cochat.ai/papers/10.1084/jem.154.3.688
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Wooley, P. H., Luthra, H. S., Stuart, J. M., & David, C. S. (1981). Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. The Journal of experimental medicine. https://doi.org/10.1084/jem.154.3.688

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.