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Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.
Open accessAbstract
A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.
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Cited by
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Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response
Labasi, J. M., Petrushova, N., Donovan, C., McCurdy, S., Lira, P., Payette, M. M., Brissette, W., Wicks, J. R., Audoly, L., & Gabel, C. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6436 · Cited by 490
Interleukin 6 plays a key role in the development of antigen-induced arthritis
Ohshima, S., Saeki, Y., Mima, T., Sasai, M., Nishioka, K., Nomura, S., Kopf, M., Katada, Y., Tanaka, T., Suemura, M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8222 · Cited by 406
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Johansson, A. C. M., Hansson, A.-S., Nandakumar, K. S., Bäcklund, J., & Holmdahl, R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3505 · Cited by 96
Metadata
- Authors
- Wooley, P. H., Luthra, H. S., Stuart, J. M., & David, C. S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-09-01
- Volume
- 154
- Issue
- 3
- Pages
- 688-700
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2040937120
- Cited by
- 687
- References
- 0
- FWCI
- 13.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. https://app.cochat.ai/papers/10.1084/jem.154.3.688
- The paper
- Wooley, P. H., Luthra, H. S., Stuart, J. M., & David, C. S. (1981). Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. The Journal of experimental medicine. https://doi.org/10.1084/jem.154.3.688
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.