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Activation of human macrophages. Comparison of other cytokines with interferon-gamma.
Open accessAbstract
Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.
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Citations
Cited by
Microglial M1/M2 polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070
Johnston, R. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803243181205 · Cited by 699
Immune interferon: a pleiotropic lymphokine with multiple effects
Trinchieri, G., & Perussia, B. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90080-5 · Cited by 658
Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W. H., Marks, M. S., Levi, B. Z., Flanagan, J. R., Appella, E., & Ozato, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3743 · Cited by 356
Byrd, T. F., & Horwitz, M. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114038 · Cited by 320
Metadata
- Authors
- Nathan, C. F., Prendergast, T. J., Wiebe, M. E., Stanley, E. R., Platzer, E., Remold, H. G., Welte, K., Rubin, B. Y., & Murray, H. W.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1984-08-01
- Volume
- 160
- Issue
- 2
- Pages
- 600-605
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2106639420
- Cited by
- 359
- References
- 0
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Activation of human macrophages. Comparison of other cytokines with interferon-gamma. https://app.cochat.ai/papers/10.1084/jem.160.2.600
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- Nathan, C. F., Prendergast, T. J., Wiebe, M. E., Stanley, E. R., Platzer, E., Remold, H. G., Welte, K., Rubin, B. Y., & Murray, H. W. (1984). Activation of human macrophages. Comparison of other cytokines with interferon-gamma. The Journal of experimental medicine. https://doi.org/10.1084/jem.160.2.600
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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