The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Response of resting human peripheral blood natural killer cells to interleukin 2.
Open accessAbstract
The present study shows that recombinant interleukin 2 (IL-2) purified to homogeneity induces a rapid and potent enhancement of spontaneous cytotoxicity of human peripheral blood lymphocytes. The cells mediating cytotoxicity after 18-h treatment with IL-2 have surface markers of natural killer (NK) cells and are generated from the peripheral blood subset containing spontaneous cytotoxic cells. A parallel production of gamma interferon (IFN-gamma) is induced by recombinant IL-2 (rIL-2), and NK cells appear to be the major producer cells, whereas T cells are unable to produce IFN-gamma under these experimental conditions. However, the kinetics of the enhancement of cytotoxicity are faster than those of IFN-gamma production, and monoclonal anti-IFN-gamma antibodies do not suppress this effect, making it unlikely that the IFN-gamma produced is responsible for the enhancement. The enhancement of NK cell activity induced by rIL-2 precedes any proliferative response of the lymphocytes, which is instead observed in longer-term cultures of both NK and T cells.
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Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
Self-citationCAR-NK cells: A promising cellular immunotherapy for cancer
Xie, G., Dong, H., Liang, Y., Ham, J. D., Rizwan, R., & Chen, J. (2020) · eBioMedicine · doi:10.1016/j.ebiom.2020.102975 · Cited by 800
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Trinchieri, G. (1998) · Advances in Immunology · doi:10.1016/s0065-2776(08)60387-9 · Cited by 760
Self-citationImmune interferon: a pleiotropic lymphokine with multiple effects
Trinchieri, G., & Perussia, B. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90080-5 · Cited by 658
Self-citationCaligiuri, M. A., Zmuidzinas, A., Manley, T. J., Levine, H., Smith, K. A., & Ritz, J. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.5.1509 · Cited by 435
Metadata
- Authors
- Trinchieri, G., Matsumoto-Kobayashi, M., Clark, S. C., Seehra, J., London, L., & Perussia, B.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1984-10-01
- Volume
- 160
- Issue
- 4
- Pages
- 1147-1169
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2104417744
- Cited by
- 604
- References
- 1
- FWCI
- 16.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Trinchieri, G., Matsumoto-Kobayashi, M., Clark, S. C., Seehra, J., London, L., & Perussia, B. (1984). Response of resting human peripheral blood natural killer cells to interleukin 2. The Journal of experimental medicine. https://doi.org/10.1084/jem.160.4.1147
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
