The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.
Open accessAbstract
We have found markedly deficient expression of the class I major histocompatibility antigens HLA-A,B,C and beta 2m on human small-cell lung cancer (SCLC) lines and fresh tumor samples. The deficit of HLA-A,B,C and beta 2-microglobulin (beta 2m) antigen expression was demonstrated with both radiobinding assays and indirect immunofluorescence assays. Immunoprecipitation of metabolically labeled cells with antibodies to class I antigens showed most SCLC lines to have synthesized almost no beta 2m and HLA-A,B,C proteins. Northern blot analysis, using human HLA-A,B, and beta 2m cDNA probes, showed that almost all SCLC lines tested had markedly decreased amounts of HLA and beta 2m mRNA, but both gene products could be induced with interferon treatment of SCLC lines. We conclude that human SCLC, in contrast to other lung cancer types, is characterized by greatly reduced transcription of HLA-A,B,C and beta 2m genes, which suggests the existence of a mechanism for evading the host immune response to the tumor and of an E1a-like product in this type of tumor cell.
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Cites
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
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Natural history of HLA expression during tumour development
Garrido, F., Cabrera, T., Concha, A., Glew, S., Ruiz-Cabello, F., & Stern, P. L. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90264-l · Cited by 448
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Metadata
- Authors
- Doyle, A., Martin, W. J., Funa, K., Gazdar, A., Carney, D., Martin, S. E., Linnoila, I., Cuttitta, F., Mulshine, J., & Bunn, P.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1985-05-01
- Volume
- 161
- Issue
- 5
- Pages
- 1135-1151
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2103973613
- Cited by
- 382
- References
- 1
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer. https://app.cochat.ai/papers/10.1084/jem.161.5.1135
- The paper
- Doyle, A., Martin, W. J., Funa, K., Gazdar, A., Carney, D., Martin, S. E., Linnoila, I., Cuttitta, F., Mulshine, J., & Bunn, P. (1985). Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer. The Journal of experimental medicine. https://doi.org/10.1084/jem.161.5.1135
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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