The DOI matches its Crossref record.
Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages.
Open accessAbstract
The rat W3/25 antigen that appears to be equivalent to human CD4 (T4) antigen is expressed on thymocytes and T helper cells and plays a role in the response of T helper cells to antigen. The W3/25 and anti-T4 antibodies also label macrophages. In this paper we examine whether the macrophage antigen is the same as that on T cells. New monoclonal antibodies against the rat CD4 antigen, MRC OX-35 through OX-38, are described, all of which label peritoneal macrophages from normal and athymic rats. The molecular weight of W3/25 antigen on macrophages is indistinguishable from that on T cells. We conclude that macrophages express authentic CD4 (W3/25) antigen. Another new monoclonal antibody, MRC OX-34, labels an antigen of 50-54,000 mol wt that is expressed on rat T but not B cells or peritoneal macrophages. It was used to control for the presence of any T cell products in immunoprecipitation from rat macrophage extracts.
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Citations
Cited by
Tacke, M., Hanke, G., Hanke, T., & Hünig, T. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270136 · Cited by 163
Dick, A. D., Ford, A. L., Forrester, J. V., & Sedgwick, J. D. (1995) · British Journal of Ophthalmology · doi:10.1136/bjo.79.9.834 · Cited by 129
Contribution of mononuclear leucocytes to the progression of experimental focal glomerular sclerosis
Saito, T., & Atkins, R. C. (1990) · Kidney International · doi:10.1038/ki.1990.88 · Cited by 96
Andjus, P. R., Bataveljić, D., Vanhoutte, G., Mitrecic, D., Pizzolante, F., Djogo, N., Nicaise, C., Kengne, F. G., Gangitano, C., Michetti, F., et al. (2009) · The Anatomical Record · doi:10.1002/ar.20995 · Cited by 65
Metadata
- Authors
- Jefferies, W. A., Green, J. R., & Williams, A. F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1985-07-01
- Volume
- 162
- Issue
- 1
- Pages
- 117-127
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2151567849
- Cited by
- 344
- References
- 0
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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