The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential.
Open accessAbstract
Lethal infections are associated with cellular dysfunction as evidenced by a decrease in the resting transmembrane potential difference (Em) of skeletal muscle fibers. Endotoxin stimulation of macrophages evokes production of cachectin, a protein that has been implicated as a mediator of the lethal effects of endotoxemia. In the present study, rat skeletal muscle fiber Em decreased when incubated with recombinant human cachectin. The reduction of Em induced by cachectin occurred in a dose-related fashion and was inhibited by mAb against the monokine. Infusion of cachectin induced a decline of skeletal muscle Em in vivo, and suggests that cachectin may acutely mediate alterations of skeletal muscle membrane function after infection.
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Citations
Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
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Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citationTumor necrosis factor: a pleiotropic cytokine and therapuetic target
Tracey, M. D., & Cerami, P. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.491 · Cited by 1,063
Tumour necrosis factor-α induces ectopic activity in nociceptive primary afferent fibres
Sorkin, L. S., Xiao, W.-H., Wagner, R., & Myers, R. R. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00147-4 · Cited by 503
Sherry, B., & Cerami, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1269 · Cited by 432
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Metadata
- Authors
- Tracey, K. J., Lowry, S. F., Beutler, B., Cerami, A., Albert, J. D., & Shires, G. T.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-10-01
- Volume
- 164
- Issue
- 4
- Pages
- 1368-1373
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2031237140
- Cited by
- 171
- References
- 1
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Tracey, K. J., Lowry, S. F., Beutler, B., Cerami, A., Albert, J. D., & Shires, G. T. (1986). Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential. The Journal of experimental medicine. https://doi.org/10.1084/jem.164.4.1368
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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