The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.
Open accessAbstract
IFN-gamma permits the endotoxin-induced production of cachectin by C3H/HeJ (endotoxin resistant) macrophages, apparently by facilitating endotoxin-induced cachectin biosynthesis at both transcriptional and posttranscriptional levels. IFN-gamma cannot induce cachectin biosynthesis by itself, nor does it markedly enhance cachectin production by endotoxin-induced peritoneal macrophages obtained from endotoxin-responsive mice. Elucidation of the precise mechanism through which IFN-gamma influences cachectin biosynthesis may permit a better understanding of the molecular events that follow endotoxin-induced activation of macrophages. Moreover, the permissive effect of IFN-gamma on cachectin biosynthesis might elicit enhanced endotoxin sensitivity in vivo.
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Citations
Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citation
Cited by
Kindler, V., Sappino, A.-P., Grau, G. E., Piguet, P.-F., & Vassalli, P. (1989) · Cell · doi:10.1016/0092-8674(89)90676-4 · Cited by 1,254
Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling
Vlassara, H., Brownlee, M., Manogue, K. R., Dinarello, C. A., & Pasagian, A. (1988) · Science · doi:10.1126/science.3259727 · Cited by 597
Kamijo, R., Le, J., Shapiro, D., Havell, E. A., Huang, S., Aguet, M., Bosland, M., & Vilcek, J. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.4.1435 · Cited by 351
Rehli, M., Poltorak, A., Schwarzfischer, L., Krause, S. W., Andreesen, R., & Beutler, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9773 · Cited by 233
Self-citationEnhancement of experimental metastasis by tumor necrosis factor.
Orosz, P., Echtenacher, B., Falk, W., Rüschoff, J., Weber, D., & Männel, D. N. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.5.1391 · Cited by 198
Metadata
- Authors
- Beutler, B., Tkacenko, V, Milsark, I., Krochin, N., & Cerami, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-11-01
- Volume
- 164
- Issue
- 5
- Pages
- 1791-1796
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2044667589
- Cited by
- 235
- References
- 1
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype. https://app.cochat.ai/papers/10.1084/jem.164.5.1791
- The paper
- Beutler, B., Tkacenko, V, Milsark, I., Krochin, N., & Cerami, A. (1986). Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype. The Journal of experimental medicine. https://doi.org/10.1084/jem.164.5.1791
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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