Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.
Open accessAbstract
Synthesis of B cell-stimulating factor-2 (BSF-2) and IFN-gamma was shown in cerebrospinal fluids (CSF) collected from mice with experimental viral meningitis. In the CSF, the level of BSF-2 started to increase 24 h after intracerebral infection with lymphocytic choriomeningitis virus (LCMV) with rapid increase after day 4. IFN-gamma was not detected in the CSF before day 5 or 6 after infection, but increased sharply thereafter. In athymic nude mice, LCMV infection did not result in meningitis, and both BSF-2 and IFN-gamma levels were only slightly and transiently elevated. These findings suggest that activated mature T cells are required for development of disease and production of both BSF-2 and IFN-gamma. As observed in mice, BSF-2 was also detected in 16 out of 19 CSF samples collected from patients with acute viral infections of the central nervous system (CNS). Intrathecal production of BSF-2 and IFN-gamma may be instrumental in local production of antiviral antibodies by B lymphocytes/plasma cells invading the CNS during viral CNS disease.
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In a murine viral meningitis model infected with lymphocytic choriomeningitis virus, levels of both IL-6 and INF-γ were elevated in CSF.
“One study using a murine viral meningitis model in which mice were infected with lymphocytic choriomeningitis virus (LCMV) showed elevated levels of both IL-6 and INF-γ in CSF [50].”
From Viral meningitis: an overview (2021) · cites this paper as [50]
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References 14 · Cited by 245
- Authors
- Frei, K., Leist, T. P., Meager, A., Gallo, P., Leppert, D., Zinkernagel, R. M., & Fontana, A.
- Affiliations
- University Hospital Zurich (CH)
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-07-01
- Volume
- 168
- Issue
- 1
- Pages
- 449-453
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2188985
- OpenAlex
- W2155086540
- Cited by
- 245
- References
- 14
- Citations by year
- 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 2
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- B cell stimulatory factor 2, interferon-gamma, viral meningitis, encephalitis, lymphocytic choriomeningitis virus, cerebrospinal fluid, nude mice, T cell activation, antiviral antibodies, B cells, plasma cells, mouse model
- MeSH terms
- Adult, Animals, Encephalitis, Female, Herpes Simplex, Humans, Interferon-gamma, Interleukins, Kinetics, Lymphocytic choriomeningitis virus, Male, Meningitis, Viral, Mice, Inbred C57BL, Mice, Nude, Interleukin-6, Mice
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