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Tumor necrosis factor identified in multiple sclerosis brain.
Open accessAbstract
Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF. In brain lesions in MS, and subacute sclerosing panencephalitis, TNF+ cells were demonstrated. At the lesion site in MS, TNF+ staining is associated with both astrocytes and macrophages. These observations were not made in Alzheimer's disease or normal brain tissue. The presence of TNF in MS lesions suggests a significant role for cytokines and the immune response in disease progression.
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Cited by
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B., & Mucke, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10061 · Cited by 1,006
Regulation of tumour necrosis factor signalling: live or let die
Brenner, D., Blaser, H., & Mak, T. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3834 · Cited by 998
Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis
Lucchinetti, C. F., Brück, W., Rodriguez, M., & Lassmann, H. (1996) · Brain Pathology · doi:10.1111/j.1750-3639.1996.tb00854.x · Cited by 733
Khoury, S. J., Hancock, W. W., & Weiner, H. L. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.5.1355 · Cited by 708
Wolswijk, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00601.1998 · Cited by 562
Metadata
- Authors
- Hofman, F. M., Hinton, D. R., Johnson, K., & Merrill, J. E.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-08-01
- Volume
- 170
- Issue
- 2
- Pages
- 607-612
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2135271960
- Cited by
- 801
- References
- 0
- FWCI
- 29.11
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Tumor necrosis factor identified in multiple sclerosis brain. https://app.cochat.ai/papers/10.1084/jem.170.2.607
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- Hofman, F. M., Hinton, D. R., Johnson, K., & Merrill, J. E. (1989). Tumor necrosis factor identified in multiple sclerosis brain. The Journal of experimental medicine. https://doi.org/10.1084/jem.170.2.607
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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