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Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family.
Open accessAbstract
In the present study, we showed that activation of human CD4 T cells can be induced by anti-CD3 and collagen in a serum-free system. This activation was inhibited by the addition of peptides containing the RGD or Gly-Pro-X sequences. Significantly, we demonstrated that both the 1F7 (CD26) structure and the VLA integrin family, particularly the VLA-3 complex, contribute to the functional interaction between collagen and CD4 cells since anti-1F7 and anti-VLA-3 specifically inhibited this collagen-induced CD4 cell activation. Biochemical studies showed that the 1F7 structure is not a member of the VLA integrin family. These results thus indicated that two different families of antigens serve as functional collagen receptors for CD4 T cell activation.
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Citations
Cited by
Lambeir, A.-M., Durinx, C., Scharpé, S., & De Meester, I. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609354 · Cited by 955
Nathan, C., & Sporn, M. (1991) · The Journal of cell biology · doi:10.1083/jcb.113.5.981 · Cited by 800
Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes
Carter, W. G., Ryan, M. C., & Gahr, P. J. (1991) · Cell · doi:10.1016/0092-8674(91)90092-d · Cited by 759
Direct Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26
Kameoka, J., Tanaka, T., Nojima, Y., Schlossman, S. F., & Morimoto, C. (1993) · Science · doi:10.1126/science.8101391 · Cited by 507
Self-citationThe multifunctional or moonlighting protein CD26/DPPIV
Boonacker, E., & Van Noorden, C. J. F. (2003) · European Journal of Cell Biology · doi:10.1078/0171-9335-00302 · Cited by 337
Metadata
- Authors
- Dang, N. H., Torimoto, Y., Schlossman, S. F., & Morimoto, C.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-08-01
- Volume
- 172
- Issue
- 2
- Pages
- 649-652
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2095326273
- Cited by
- 171
- References
- 0
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Dang, N. H., Torimoto, Y., Schlossman, S. F., & Morimoto, C. (1990). Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family. The Journal of experimental medicine. https://doi.org/10.1084/jem.172.2.649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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