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Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8.
Open accessAbstract
After phagocytosis of yeast opsonized with IgG, neutrophil leukocytes (polymorphonuclear leukocytes [PMN]) expressed high levels of neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) mRNA, which peaked after 3-5 h and were still elevated after 18 h. A similar but quantitatively less prominent effect was obtained with lipopolysaccharide (LPS). After phagocytosis, but not after exposure to LPS, the PMN progressively released considerable amounts of NAP-1/IL-8 into the culture medium (18.6-50 ng/ml in 18 h). The peptide released was biologically active, as indicated by the transient elevation of cytosolic-free calcium in PMN exposed to aliquots of the culture supernatants, and desensitization by prestimulation of the cells with recombinant NAP-1/IL-8. By producing NAP-1/IL-8 at sites where they phagocytose invading microorganisms, PMN could enhance the recruitment of new defense cells.
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Citations
Cited by
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Cassatella, M. A. (1999) · Advances in Immunology · doi:10.1016/s0065-2776(08)60791-9 · Cited by 560
Self-citationActivation of the NF-κB Pathway by Inflammatory Stimuli in Human Neutrophils
McDonald, P. P., Bald, A., & Cassatella, M. A. (1997) · Blood · doi:10.1182/blood.v89.9.3421 · Cited by 324
Self-citationThe IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing
Zinkernagel, A. S., Timmer, A. M., Pence, M. A., Locke, J. B., Buchanan, J. T., Turner, C. E., Mishalian, I., Sriskandan, S., Hanski, E., & Nizet, V. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.07.002 · Cited by 184
“IL-8, formerly known as neutrophil activating peptide-1, is produced in large amounts by neutrophils themselves upon encountering bacteria (Bazzoni et al., 1991; Strieter et al., 1992), and in an autocrine fashion can exert stimulatory effects on oxidative burst function and release of granule…”
BackgroundFujishima, S., Hoffman, A. R., Vu, T., Kim, K. J., Zheng, H., Daniel, D., Kim, Y., Wallace, E. F., Larrick, J. W., & Raffin, T. A. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041540305 · Cited by 151
Metadata
- Authors
- Bazzoni, F., Cassatella, M. A., Rossi, F., Ceska, M., Dewald, B., & Baggiolini, M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-03-01
- Volume
- 173
- Issue
- 3
- Pages
- 771-774
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2100295490
- Cited by
- 436
- References
- 0
- FWCI
- 18.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8. https://app.cochat.ai/papers/10.1084/jem.173.3.771
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- Bazzoni, F., Cassatella, M. A., Rossi, F., Ceska, M., Dewald, B., & Baggiolini, M. (1991). Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8. The Journal of experimental medicine. https://doi.org/10.1084/jem.173.3.771
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