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An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.
Open accessAbstract
The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-alpha locus. This is biallelic and lies within the promoter region. Frequency analysis of the TNF-alpha polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism, in HLA-typed individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles. This is the first association between TNF-alpha and other MHC alleles and raises the possibility that the uncommon TNF-alpha allele may contribute to the many autoimmune associations of the A1,B8,DR3 haplotype.
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Citations
Cited by
BOUMA, G., CRUSIUS, J. B. A., OUDKERK POOL, M., KOLKMAN, J. J., VON BLOMBERG, B. M. E., KOSTENSE, P. J., GIPHART, M. J., SCHREUDER, G. M. T., MEUWISSEN, S. G. M., & PEÑA, A. S. (1996) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1996.d01-65.x · Cited by 373
Genetic susceptibility to adverse drug reactions
Pirmohamed, M., & Park, B. K. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01717-x · Cited by 328
Cerebral pattern of pro- and anti-inflammatory cytokines in dementias
Tarkowski, E., Liljeroth, A.-M., Minthon, L., Tarkowski, A., Wallin, A., & Blennow, K. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00088-1 · Cited by 219
Frequency and nature of cytokine gene polymorphisms in type 1 autoimmune hepatitis
Cookson, S., Constantini, P. K., Clare, M., Underhill, J. A., Bernal, W., Czaja, A. J., & Donaldson, P. T. (1999) · Hepatology · doi:10.1002/hep.510300412 · Cited by 180
Metadata
- Authors
- Wilson, A. G., de Vries, N., Pociot, F., di Giovine, F. S., van der Putte, L. B., & Duff, G. W.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-02-01
- Volume
- 177
- Issue
- 2
- Pages
- 557-560
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2134193741
- Cited by
- 675
- References
- 0
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. https://app.cochat.ai/papers/10.1084/jem.177.2.557
- The paper
- Wilson, A. G., de Vries, N., Pociot, F., di Giovine, F. S., van der Putte, L. B., & Duff, G. W. (1993). An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. The Journal of experimental medicine. https://doi.org/10.1084/jem.177.2.557
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
