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Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
Open accessAbstract
The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells. We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor. Moreover, we have now cloned both the cDNA and the gene for this receptor, functionally expressed the receptor in Xenopus oocytes, and mapped the gene to human chromosome 3p21. Transcripts for the receptor were found in mature and immature myeloid cells as well as B cells. The receptor is a member of the G protein-coupled receptor superfamily. It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.
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Citations
Cited by
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
Self-citationCole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2009 · Cited by 870
Gao, J.-L., Wynn, T. A., Chang, Y., Lee, E. J., Broxmeyer, H. E., Cooper, S., Tiffany, H. L., Westphal, H., Kwon-Chung, J., & Murphy, P. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.11.1959 · Cited by 441
Self-citation(1999) · PubMed · Cited by 207
Metadata
- Authors
- Gao, J. L., Kuhns, D. B., Tiffany, H. L., McDermott, D., Li, X., Francke, U., & Murphy, P. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-05-01
- Volume
- 177
- Issue
- 5
- Pages
- 1421-1427
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2099768074
- Cited by
- 342
- References
- 0
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Gao, J. L., Kuhns, D. B., Tiffany, H. L., McDermott, D., Li, X., Francke, U., & Murphy, P. M. (1993). Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. The Journal of experimental medicine. https://doi.org/10.1084/jem.177.5.1421
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