The DOI matches its Crossref record.
Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.
Open accessAbstract
The nef gene product encoded by the mac239 proviral clone of simian immunodeficiency virus (SIV) markedly enhances viral replication and pathogenesis in vivo. We have used this biologically active nef isolate to examine the phenotype of Nef in retrovirally transduced human T cells in culture. SIV Nef is shown to dramatically inhibit cell-surface expression of the CD4 glycoprotein without significantly affecting the total steady-state level of cellular CD4. This downregulation of the cell-surface CD4 receptor for human immunodeficiency virus type 1 (HIV-1) infection correlated with the acquisition of resistance to superinfection by HIV-1. However, SIV Nef did not affect the level of gene expression directed by the HIV-1 long terminal repeat. It is hypothesized that downregulation of cell-surface CD4 by Nef facilitates the efficient release of infectious progeny virions and, hence, viral spread in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Aiken, C., Konner, J., Landau, N. R., Lenburg, M. E., & Trono, D. (1994) · Cell · doi:10.1016/0092-8674(94)90360-3 · Cited by 695
Saksela, K., Cheng, G., & Baltimore, D. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07024.x · Cited by 552
Miller, M. D., Warmerdam, M. T., Gaston, I., Greene, W. C., & Feinberg, M. B. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.1.101 · Cited by 527
Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2
Jia, B., Serra-Moreno, R., Neidermyer, W., Rahmberg, A., Mackey, J., Fofana, I. B., Johnson, W. E., Westmoreland, S., & Evans, D. T. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000429 · Cited by 406
Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
Chowers, M. Y., Spina, C. A., Kwoh, T. J., Fitch, N. J., Richman, D. D., & Guatelli, J. C. (1994) · Journal of Virology · doi:10.1128/jvi.68.5.2906-2914.1994 · Cited by 364
Metadata
- Authors
- Benson, R. E., Sanfridson, A., Ottinger, J. S., Doyle, C., & Cullen, B. R.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-06-01
- Volume
- 177
- Issue
- 6
- Pages
- 1561-1566
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2162126058
- Cited by
- 292
- References
- 0
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. https://app.cochat.ai/papers/10.1084/jem.177.6.1561
- The paper
- Benson, R. E., Sanfridson, A., Ottinger, J. S., Doyle, C., & Cullen, B. R. (1993). Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. The Journal of experimental medicine. https://doi.org/10.1084/jem.177.6.1561
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
