The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.
Open accessAbstract
Mice with homologous disruption of the interferon gamma (IFN-gamma) gene on the C57BL/6 background were infected with Leishmania major and the immune response assessed. In contrast to wild-type or heterozygous knockout mice, deficient animals were unable to restrict growth of the parasite and suffered lethal infection over 6-8 wk. Although wild-type and heterozygous littermates developed CD4+ cells that contained transcripts for IFN-gamma and lymphotoxin, typical of T helper type 1 (Th1) cells, the knockout mice developed CD4+ cells that contained transcripts for interleukin 4 (IL-4), IL-5, and IL-13, typical of Th2 cells. ELISPOT assays confirmed the reciprocal patterns of IFN-gamma or IL-4 production by T cells in similar frequencies in the respective groups of mice, and antibody analysis confirmed the presence of Th2-mediated isotype switching in the knockout mice. These data suggest that CD4+ T cells that normally respond to antigens by differentiation to Th1 cells default to the Th2 pathway in the absence of endogenous IFN-gamma.
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Cites
Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954
Cited by
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Darrah, P. A., Patel, D. T., De Luca, P. M., Lindsay, R. W. B., Davey, D. F., Flynn, B. J., Hoff, S. T., Andersen, P., Reed, S. G., Morris, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1592 · Cited by 1,378
The Central Role of CD4+ T Cells in the Antitumor Immune Response
Hung, K., Hayashi, R., Lafond-Walker, A., Lowenstein, C., Pardoll, D., & Levitsky, H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2357 · Cited by 1,345
The immunology of susceptibility and resistance to Leishmania major in mice
Sacks, D., & Noben-Trauth, N. (2002) · Nature Reviews Immunology · doi:10.1038/nri933 · Cited by 1,208
Molecular Mechanisms RegulatinG Th1 Immune Responses
Szabo, S. J., Sullivan, B. M., Peng, S. L., & Glimcher, L. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140942 · Cited by 1,019
Metadata
- Authors
- Wang, Z. E., Reiner, S. L., Zheng, S., Dalton, D. K., & Locksley, R. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-04-01
- Volume
- 179
- Issue
- 4
- Pages
- 1367-1371
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2046954690
- Cited by
- 392
- References
- 1
- FWCI
- 11.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, Z. E., Reiner, S. L., Zheng, S., Dalton, D. K., & Locksley, R. M. (1994). CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. The Journal of experimental medicine. https://doi.org/10.1084/jem.179.4.1367
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