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Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.
Open accessAbstract
We describe mice that express a transgenic T cell receptor alpha/beta (TCR-alpha/beta) specific for peptide 111-119 from influenza hemagglutinin presented by I-Ed class II major histocompatibility complex (MHC) molecules. The transgenic TCR is expressed on CD4+8- as well as CD4-8+ mature T cells even in mice that are deficient in rearrangement or do not express endogenous TCR-alpha genes. The CD4-8+ T cells require I-Ed class II MHC molecules for positive selection and can be activated to proliferate and to kill by I-Ed molecules presenting the relevant peptide. Full maturation of these cells, however, also requires the presence of class I MHC molecules. The results are compatible with the notion that T cell maturation requires multiple receptor-ligand interactions and establish an exception to the rule that class II-restricted TCRs are exclusively expressed by mature CD4+8- cells.
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Metadata
- Authors
- Kirberg, J., Baron, A., Jakob, S., Rolink, A., Karjalainen, K., & von Boehmer, H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-07-01
- Volume
- 180
- Issue
- 1
- Pages
- 25-34
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2092095871
- Cited by
- 410
- References
- 0
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Kirberg, J., Baron, A., Jakob, S., Rolink, A., Karjalainen, K., & von Boehmer, H. (1994). Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. The Journal of experimental medicine. https://doi.org/10.1084/jem.180.1.25
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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