The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor.
Open accessAbstract
The human OX-40 cell surface antigen is a CD4+ T cell activation marker that acts as a costimulatory receptor and is a member of the nerve growth factor receptor/tumor necrosis factor (TNF) receptor family. Using a soluble form of the receptor, the extracellular region fused with human immunoglobulin Fc, we expression cloned the human OX-40 ligand cDNA from a library derived from an activated B lymphoblastoid cell line MSAB. The encoded protein is identified as gp34, a type II transmembrane antigen previously known to be expressed only by human T cell lymphotropic virus 1-infected cells. We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation.
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Schwartz, R. H. (1992) · Cell · doi:10.1016/s0092-8674(05)80055-8 · Cited by 1,293
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Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses
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Metadata
- Authors
- Godfrey, W. R., Fagnoni, F. F., Harara, M. A., Buck, D., & Engleman, E. G.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-08-01
- Volume
- 180
- Issue
- 2
- Pages
- 757-762
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2063480372
- Cited by
- 271
- References
- 1
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Godfrey, W. R., Fagnoni, F. F., Harara, M. A., Buck, D., & Engleman, E. G. (1994). Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. The Journal of experimental medicine. https://doi.org/10.1084/jem.180.2.757
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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