The DOI matches its Crossref record.
Novel packages of viral and self-antigens are generated during apoptosis.
Open accessAbstract
Immune context is an essential determinant of the host response to potential autoantigens. The clustering of the autoantigens targeted in systemic lupus erythematosus within surface blebs of apoptotic cells generates high concentrations of autoantigen within discrete subcellular packages. We demonstrate here that when apoptosis is induced by Sindbis virus infection, viral antigens and autoantigens cocluster exclusively in small surface blebs of apoptotic cells. The surface of these blebs is rich in viral glycoproteins, and virions can be seen blebbing from their surface. We propose that these blebs of mixed foreign and self-origin define a novel immune context that may challenge self-tolerance.
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Cited by
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik, M. J., Craft, J. E., & Mamula, M. J. (2001) · Nature Reviews Immunology · doi:10.1038/35100573 · Cited by 572
The Role of Complement in the Development of Systemic Lupus Erythematosus
Manderson, A. P., Botto, M., & Walport, M. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104549 · Cited by 538
Atkin-Smith, G. K., Tixeira, R., Paone, S., Mathivanan, S., Collins, C., Liem, M., Goodall, K. J., Ravichandran, K. S., Hulett, M. D., & Poon, I. K. H. (2015) · Nature Communications · doi:10.1038/ncomms8439 · Cited by 398
C1q and Systemic Lupus Erythematosus
Walport, M. J., Davies, K. A., & Botto, M. (1998) · Immunobiology · doi:10.1016/s0171-2985(98)80032-6 · Cited by 393
Metadata
- Authors
- Rosen, A., Casciola-Rosen, L., & Ahearn, J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-04-01
- Volume
- 181
- Issue
- 4
- Pages
- 1557-1561
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2135752753
- Cited by
- 246
- References
- 0
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rosen, A., Casciola-Rosen, L., & Ahearn, J. (1995). Novel packages of viral and self-antigens are generated during apoptosis. The Journal of experimental medicine. https://doi.org/10.1084/jem.181.4.1557
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
